ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Voltage-dependent L-type calcium channel subunit alpha-1S

Intramolecular
Cysteine 1338 and cysteine 1352
Cysteine 957 and cysteine 968
Cysteine 226 and cysteine 254
Cysteine 245 and cysteine 261
Cysteine 226 and cysteine 261
Cysteine 245 and cysteine 254
Cysteine 226 and cysteine 245
Cysteine 501 and cysteine 505
Cysteine 1439 and cysteine 1445
Cysteine 254 and cysteine 261
More...
Cysteine 1319 and cysteine 1368
Cysteine 1319 and cysteine 1332
Cysteine 1332 and cysteine 1352
Cysteine 529 and cysteine 944
A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 1338 and 1352.

Details

Redox score ?
87
PDB code
6jpb
Structure name
rabbit cav1
Structure deposition date
2019-03-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07293
Residue number A
1338
Residue number B
1352
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 1338 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1352 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 957 and 968.

Details

Redox score ?
87
PDB code
7jpl
Structure name
rabbit cav1
Structure deposition date
2020-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07293
Residue number A
957
Residue number B
968
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 957 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 968 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 226 and 254.

Details

Redox score ?
85
PDB code
8e57
Structure name
rabbit l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07293
Residue number A
226
Residue number B
254
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 226 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 245 and 261.

Details

Redox score ?
80
PDB code
7jpk
Structure name
rabbit cav1
Structure deposition date
2020-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07293
Residue number A
245
Residue number B
261
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 245 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 226 and 261.

Details

Redox score ?
75
PDB code
6byo
Structure name
residue assignment correction to the voltage gated calcium cav1
Structure deposition date
2017-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07293
Residue number A
226
Residue number B
261
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 226 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 245 and 254.

Details

Redox score ?
68
PDB code
6jpb
Structure name
rabbit cav1
Structure deposition date
2019-03-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide accession
P07293
Residue number A
245
Residue number B
254
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 245 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 226 and 245.

Details

Redox score ?
67
PDB code
5gjw
Structure name
structure of the mammalian voltage-gated calcium channel cav1
Structure deposition date
2016-07-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07293
Residue number A
226
Residue number B
245
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 226 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 501 and 505.

Details

Redox score ?
61
PDB code
6jp5
Structure name
rabbit cav1
Structure deposition date
2019-03-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
4
Peptide accession
P07293
Residue number A
501
Residue number B
505
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 501 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 505 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 1439 and 1445. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6jp8
Structure name
rabbit cav1
Structure deposition date
2019-03-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
30
Minimum pKa ?
9
% buried
0
Peptide accession
P07293
Residue number A
1439
Residue number B
1445
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 1439 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1445 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 254 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
8e57
Structure name
rabbit l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07293
Residue number A
254
Residue number B
261
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 254 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 1319 and 1368. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5gjw
Structure name
structure of the mammalian voltage-gated calcium channel cav1
Structure deposition date
2016-07-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
84
Peptide accession
P07293
Residue number A
1319
Residue number B
1368
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 1319 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1368 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 1319 and 1332. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7jpl
Structure name
rabbit cav1
Structure deposition date
2020-08-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
P07293
Residue number A
1319
Residue number B
1332
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 1319 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1332 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 1332 and 1352. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6jp8
Structure name
rabbit cav1
Structure deposition date
2019-03-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
76
Peptide accession
P07293
Residue number A
1332
Residue number B
1352
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 1332 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1352 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1S between cysteines 529 and 944. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7jpv
Structure name
rabbit cav1
Structure deposition date
2020-08-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
84
Peptide accession
P07293
Residue number A
529
Residue number B
944
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1S

Ligandability

Cysteine 529 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 944 of Voltage-dependent L-type calcium channel subunit alpha-1S

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: