Activin receptor type-2B
Intramolecular
Cysteine 49 and cysteine 77
Cysteine 84 and cysteine 103
Cysteine 29 and cysteine 59
Cysteine 29 and cysteine 49
Cysteine 90 and cysteine 102
Cysteine 104 and cysteine 109
Cysteine 90 and cysteine 104
Cysteine 29 and cysteine 77
Cysteine 59 and cysteine 109
Cysteine 49 and cysteine 59
More...Cysteine 29 and cysteine 109
Cysteine 90 and cysteine 109
Cysteine 59 and cysteine 104
Cysteine 59 and cysteine 77
Cysteine 90 and cysteine 103
Cysteine 102 and cysteine 104
Cysteine 29 and cysteine 104
Cysteine 84 and cysteine 104
Cysteine 84 and cysteine 90
Cysteine 102 and cysteine 103
Cysteine 59 and cysteine 90
Cysteine 84 and cysteine 109
Cysteine 460 and cysteine 473
Cysteine 49 and cysteine 109
Cysteine 102 and cysteine 109
Cysteine 103 and cysteine 104
Cysteine 29 and cysteine 90
Cysteine 103 and cysteine 109
Cysteine 288 and cysteine 400
Cysteine 29 and cysteine 84
Cysteine 84 and cysteine 102
Cysteine 59 and cysteine 84
Cysteine 59 and cysteine 103
Cysteine 49 and cysteine 104
Cysteine 77 and cysteine 109
Cysteine 29 and cysteine 103
Cysteine 59 and cysteine 102
2h64 C 31 C 59
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 49 and 77 (31 and 59 respectively in this structure).
Details
Redox score ?
82
PDB code
2h64
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
49
Residue number B
77
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 49 of Activin receptor type-2B
Cysteine 77 of Activin receptor type-2B
1nyu A 84 A 103
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 84 and 103.
Details
Redox score ?
81
PDB code
1nyu
Structure name
crystal structure of activin a bound to the ecd of actriib
Structure deposition date
2003-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38445
Residue number A
84
Residue number B
103
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 84 of Activin receptor type-2B
Cysteine 103 of Activin receptor type-2B
2h62 D 11 D 41
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 59 (11 and 41 respectively in this structure).
Details
Redox score ?
81
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
29
Residue number B
59
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 59 of Activin receptor type-2B
2h62 D 11 D 31
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 49 (11 and 31 respectively in this structure).
Details
Redox score ?
81
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
29
Residue number B
49
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 49 of Activin receptor type-2B
2h64 C 72 C 84
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 90 and 102 (72 and 84 respectively in this structure).
Details
Redox score ?
80
PDB code
2h64
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
90
Residue number B
102
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 90 of Activin receptor type-2B
Cysteine 102 of Activin receptor type-2B
2h62 D 86 D 91
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 104 and 109 (86 and 91 respectively in this structure).
Details
Redox score ?
77
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
104
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 104 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
1nyu A 90 A 104
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 90 and 104.
Details
Redox score ?
71
PDB code
1nyu
Structure name
crystal structure of activin a bound to the ecd of actriib
Structure deposition date
2003-02-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38445
Residue number A
90
Residue number B
104
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 90 of Activin receptor type-2B
Cysteine 104 of Activin receptor type-2B
2h64 C 11 C 59
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 77 (11 and 59 respectively in this structure).
Details
Redox score ?
70
PDB code
2h64
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
29
Residue number B
77
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 77 of Activin receptor type-2B
2h64 C 41 C 91
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 59 and 109 (41 and 91 respectively in this structure).
Details
Redox score ?
67
PDB code
2h64
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
59
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 59 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
2h62 D 31 D 41
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 49 and 59 (31 and 41 respectively in this structure).
Details
Redox score ?
65
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
49
Residue number B
59
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 49 of Activin receptor type-2B
Cysteine 59 of Activin receptor type-2B
2h62 D 11 D 91
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 109 (11 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
29
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
2h64 C 72 C 91
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 90 and 109 (72 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
2h64
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
90
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 90 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
1s4y C 37 C 82
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 59 and 104 (37 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
59
Residue number B
104
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 59 of Activin receptor type-2B
Cysteine 104 of Activin receptor type-2B
1s4y C 37 C 55
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 59 and 77 (37 and 55 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
59
Residue number B
77
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 59 of Activin receptor type-2B
Cysteine 77 of Activin receptor type-2B
2h62 D 72 D 85
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 90 and 103 (72 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
90
Residue number B
103
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 90 of Activin receptor type-2B
Cysteine 103 of Activin receptor type-2B
2h62 D 84 D 86
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 102 and 104 (84 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
102
Residue number B
104
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 102 of Activin receptor type-2B
Cysteine 104 of Activin receptor type-2B
2h64 C 11 C 86
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 104 (11 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
2h64
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
29
Residue number B
104
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 104 of Activin receptor type-2B
1s4y A 62 A 82
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 84 and 104 (62 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
84
Residue number B
104
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 84 of Activin receptor type-2B
Cysteine 104 of Activin receptor type-2B
6mac C 84 C 90
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 84 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6mac
Structure name
ternary structure of gdf11 bound to actriib-ecd and alk5-ecd
Structure deposition date
2018-08-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38445
Residue number A
84
Residue number B
90
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 84 of Activin receptor type-2B
Cysteine 90 of Activin receptor type-2B
4fao R 84 R 85
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 102 and 103 (84 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13705
Residue number A
102
Residue number B
103
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 102 of Activin receptor type-2B
Cysteine 103 of Activin receptor type-2B
1s4y C 37 C 68
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 59 and 90 (37 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
59
Residue number B
90
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 59 of Activin receptor type-2B
Cysteine 90 of Activin receptor type-2B
2h62 D 66 D 91
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 84 and 109 (66 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
84
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 84 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
2qlu A 460 A 473
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 460 and 473. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2qlu
Structure name
crystal structure of activin receptor type ii kinase domain from human
Structure deposition date
2007-07-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
62
Peptide accession
Q13705
Residue number A
460
Residue number B
473
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 460 of Activin receptor type-2B
Cysteine 473 of Activin receptor type-2B
1s4y C 27 C 87
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 49 and 109 (27 and 87 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
49
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 49 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
1nyu C 102 C 109
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 102 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
1nyu
Structure name
crystal structure of activin a bound to the ecd of actriib
Structure deposition date
2003-02-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38445
Residue number A
102
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 102 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
1nyu C 103 C 104
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 103 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
1nyu
Structure name
crystal structure of activin a bound to the ecd of actriib
Structure deposition date
2003-02-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
nan
Peptide accession
P38445
Residue number A
103
Residue number B
104
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 103 of Activin receptor type-2B
Cysteine 104 of Activin receptor type-2B
2h64 C 11 C 72
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 90 (11 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
2h64
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
29
Residue number B
90
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 90 of Activin receptor type-2B
2h62 D 85 D 91
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 103 and 109 (85 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
103
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 103 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
2qlu A 288 A 400
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 288 and 400. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2qlu
Structure name
crystal structure of activin receptor type ii kinase domain from human
Structure deposition date
2007-07-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
62
Peptide accession
Q13705
Residue number A
288
Residue number B
400
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 288 of Activin receptor type-2B
Cysteine 400 of Activin receptor type-2B
2h62 D 11 D 66
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 84 (11 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2h62
Structure name
crystal structure of a ternary ligand-receptor complex of bmp-2
Structure deposition date
2006-05-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3KQI1
Residue number A
29
Residue number B
84
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 84 of Activin receptor type-2B
5nhr C 84 C 102
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 84 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5nhr
Structure name
crystal structure of the activin receptor type-2b ligand binding domain in complex with bimagrumab fv, cubic crystal form
Structure deposition date
2017-03-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13705
Residue number A
84
Residue number B
102
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 84 of Activin receptor type-2B
Cysteine 102 of Activin receptor type-2B
4fao Q 41 Q 66
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 59 and 84 (41 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13705
Residue number A
59
Residue number B
84
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 59 of Activin receptor type-2B
Cysteine 84 of Activin receptor type-2B
1nyu A 59 A 103
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 59 and 103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
1nyu
Structure name
crystal structure of activin a bound to the ecd of actriib
Structure deposition date
2003-02-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38445
Residue number A
59
Residue number B
103
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 59 of Activin receptor type-2B
Cysteine 103 of Activin receptor type-2B
1s4y C 27 C 82
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 49 and 104 (27 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
49
Residue number B
104
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 49 of Activin receptor type-2B
Cysteine 104 of Activin receptor type-2B
1s4y C 55 C 87
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 77 and 109 (55 and 87 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
77
Residue number B
109
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 77 of Activin receptor type-2B
Cysteine 109 of Activin receptor type-2B
1nyu A 29 A 103
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 29 and 103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
1nyu
Structure name
crystal structure of activin a bound to the ecd of actriib
Structure deposition date
2003-02-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38445
Residue number A
29
Residue number B
103
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 29 of Activin receptor type-2B
Cysteine 103 of Activin receptor type-2B
1s4y C 37 C 80
A redox-regulated disulphide may form within Activin receptor type-2B between cysteines 59 and 102 (37 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
1s4y
Structure name
crystal structure of the activin/actriib extracellular domain
Structure deposition date
2004-01-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27040
Residue number A
59
Residue number B
102
Peptide name
Activin receptor type-2B
Ligandability
Cysteine 59 of Activin receptor type-2B
Cysteine 102 of Activin receptor type-2B
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