ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Spliceosome RNA helicase DDX39B

Intramolecular
Cysteine 198 and cysteine 239
Cysteine 75 and cysteine 87
Cysteine 87 and cysteine 198
A redox-regulated disulphide may form within Spliceosome RNA helicase DDX39B between cysteines 198 and 239.

Details

Redox score ?
73
PDB code
1t6n
Structure name
crystal structure of the n-terminal domain of human uap56
Structure deposition date
2004-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
87
Peptide accession
Q13838
Residue number A
198
Residue number B
239
Peptide name
Spliceosome RNA helicase DDX39B

Ligandability

Cysteine 198 of Spliceosome RNA helicase DDX39B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Spliceosome RNA helicase DDX39B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Spliceosome RNA helicase DDX39B between cysteines 75 and 87.

Details

Redox score ?
68
PDB code
1t6n
Structure name
crystal structure of the n-terminal domain of human uap56
Structure deposition date
2004-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
82
Peptide accession
Q13838
Residue number A
75
Residue number B
87
Peptide name
Spliceosome RNA helicase DDX39B

Ligandability

Cysteine 75 of Spliceosome RNA helicase DDX39B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Spliceosome RNA helicase DDX39B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Spliceosome RNA helicase DDX39B between cysteines 87 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
1t6n
Structure name
crystal structure of the n-terminal domain of human uap56
Structure deposition date
2004-05-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
16
% buried
90
Peptide accession
Q13838
Residue number A
87
Residue number B
198
Peptide name
Spliceosome RNA helicase DDX39B

Ligandability

Cysteine 87 of Spliceosome RNA helicase DDX39B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Spliceosome RNA helicase DDX39B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: