Bleomycin hydrolase

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Bleomycin hydrolase at cysteines 223 and 40. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7v5l

Structure name

crystal structure of human bleomycin hydrolase

Structure deposition date

2021-08-17

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Bleomycin hydrolase

Peptide B name

Bleomycin hydrolase

Peptide A accession

Q13867

Peptide B accession

Q13867

Peptide A residue number

223

Peptide B residue number

Ligandability

Cysteine 223 of Bleomycin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Bleomycin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bleomycin hydrolase between cysteines 221 and 223. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7xf9

Structure name

crystal structure of human bleomycin hydrolase h372a mutant

Structure deposition date

2022-04-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q13867

Residue number A

221

Residue number B

223

Peptide name

Bleomycin hydrolase

Ligandability

Cysteine 221 of Bleomycin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Bleomycin hydrolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bleomycin hydrolase between cysteines 73 and 326. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?