ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Krueppel-like factor 5

Intramolecular
Cysteine 375 and cysteine 380
Cysteine 405 and cysteine 410
Cysteine 435 and cysteine 438
A redox-regulated disulphide may form within Krueppel-like factor 5 between cysteines 375 and 380.

Details

Redox score ?
89
PDB code
2ebt
Structure name
solution structure of three tandem repeats of zf-c2h2 domains from human kruppel-like factor 5
Structure deposition date
2007-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
0
Peptide accession
Q13887
Residue number A
375
Residue number B
380
Peptide name
Krueppel-like factor 5

Ligandability

Cysteine 375 of Krueppel-like factor 5

Cysteine 380 of Krueppel-like factor 5

A redox-regulated disulphide may form within Krueppel-like factor 5 between cysteines 405 and 410.

Details

Redox score ?
88
PDB code
2ebt
Structure name
solution structure of three tandem repeats of zf-c2h2 domains from human kruppel-like factor 5
Structure deposition date
2007-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
8
% buried
2
Peptide accession
Q13887
Residue number A
405
Residue number B
410
Peptide name
Krueppel-like factor 5

Ligandability

Cysteine 405 of Krueppel-like factor 5

Cysteine 410 of Krueppel-like factor 5

A redox-regulated disulphide may form within Krueppel-like factor 5 between cysteines 435 and 438.

Details

Redox score ?
87
PDB code
2ebt
Structure name
solution structure of three tandem repeats of zf-c2h2 domains from human kruppel-like factor 5
Structure deposition date
2007-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide accession
Q13887
Residue number A
435
Residue number B
438
Peptide name
Krueppel-like factor 5

Ligandability

Cysteine 435 of Krueppel-like factor 5

Cysteine 438 of Krueppel-like factor 5

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