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a tool for identifying drug-targetable redox-active disulphides

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General transcription factor IIH subunit 2

Intermolecular
Cysteine 142 of General transcription factor IIH subunit 3 and cysteine 371
Cysteine 285 of General transcription factor IIH subunit 3 and cysteine 247
Cysteine 142 of General transcription factor IIH subunit 3 and cysteine 345
Cysteine 142 of General transcription factor IIH subunit 3 and cysteine 348
Cysteine 268 of General transcription factor IIH subunit 3 and cysteine 247
Cysteine 282 of General transcription factor IIH subunit 3 and cysteine 247
Cysteine 142 of General transcription factor IIH subunit 3 and cysteine 368
Cysteine 271 of General transcription factor IIH subunit 3 and cysteine 247
Cysteine 142 of General transcription factor IIH subunit 3 and cysteine 381
Cysteine 588 of General transcription and DNA repair factor IIH helicase subunit XPD and cysteine 177
More...
Cysteine 142 of General transcription factor IIH subunit 3 and cysteine 382
Intramolecular
Cysteine 345 and cysteine 371
Cysteine 291 and cysteine 294
Cysteine 345 and cysteine 368
Cysteine 291 and cysteine 308
Cysteine 294 and cysteine 305
Cysteine 360 and cysteine 363
Cysteine 360 and cysteine 385
Cysteine 345 and cysteine 348
Cysteine 348 and cysteine 371
Cysteine 291 and cysteine 305
Cysteine 360 and cysteine 382
Cysteine 348 and cysteine 368
Cysteine 363 and cysteine 385
Cysteine 363 and cysteine 382
Cysteine 382 and cysteine 385
Cysteine 177 and cysteine 208
Cysteine 368 and cysteine 371
Cysteine 294 and cysteine 308
Cysteine 305 and cysteine 308
Cysteine 345 and cysteine 382
Cysteine 381 and cysteine 385
Cysteine 360 and cysteine 381
Cysteine 381 and cysteine 382
Cysteine 363 and cysteine 381
Cysteine 299 and cysteine 305
Cysteine 371 and cysteine 382
A redox-regulated disulphide may form between cysteine 142 of General transcription factor IIH subunit 3 and cysteine 371 of General transcription factor IIH subunit 2.

Details

Redox score ?
71
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
86
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
142
Peptide B residue number
371

Ligandability

Cysteine 142 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 371 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 285 of General transcription factor IIH subunit 3 and cysteine 247 of General transcription factor IIH subunit 2.

Details

Redox score ?
67
PDB code
7nw0
Structure name
rna polymerase ii pre-initiation complex with open promoter dna
Structure deposition date
2021-03-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
62
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
285
Peptide B residue number
247

Ligandability

Cysteine 285 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 142 of General transcription factor IIH subunit 3 and cysteine 345 of General transcription factor IIH subunit 2.

Details

Redox score ?
61
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
nan
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
142
Peptide B residue number
345

Ligandability

Cysteine 142 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 345 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 142 of General transcription factor IIH subunit 3 and cysteine 348 of General transcription factor IIH subunit 2.

Details

Redox score ?
61
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
76
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
142
Peptide B residue number
348

Ligandability

Cysteine 142 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 348 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 268 of General transcription factor IIH subunit 3 and cysteine 247 of General transcription factor IIH subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6o9m
Structure name
structure of the human apo tfiih
Structure deposition date
2019-03-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
5
% buried
64
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
268
Peptide B residue number
247

Ligandability

Cysteine 268 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 282 of General transcription factor IIH subunit 3 and cysteine 247 of General transcription factor IIH subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7nw0
Structure name
rna polymerase ii pre-initiation complex with open promoter dna
Structure deposition date
2021-03-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
60
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
282
Peptide B residue number
247

Ligandability

Cysteine 282 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 142 of General transcription factor IIH subunit 3 and cysteine 368 of General transcription factor IIH subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
70
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
142
Peptide B residue number
368

Ligandability

Cysteine 142 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 368 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 271 of General transcription factor IIH subunit 3 and cysteine 247 of General transcription factor IIH subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7nvz
Structure name
rna polymerase ii pre-initiation complex with closed promoter dna in distal position
Structure deposition date
2021-03-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
6
% buried
66
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
271
Peptide B residue number
247

Ligandability

Cysteine 271 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 142 of General transcription factor IIH subunit 3 and cysteine 381 of General transcription factor IIH subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6o9l
Structure name
human holo-pic in the closed state
Structure deposition date
2019-03-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
100
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
142
Peptide B residue number
381

Ligandability

Cysteine 142 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 588 of General transcription and DNA repair factor IIH helicase subunit XPD and cysteine 177 of General transcription factor IIH subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5iy6
Structure name
human holo-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
39
Peptide A name
General transcription and DNA repair factor IIH helicase subunit XPD
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
P18074
Peptide B accession
Q13888
Peptide A residue number
588
Peptide B residue number
177

Ligandability

Cysteine 588 of General transcription and DNA repair factor IIH helicase subunit XPD

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 142 of General transcription factor IIH subunit 3 and cysteine 382 of General transcription factor IIH subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
76
Peptide A name
General transcription factor IIH subunit 3
Peptide B name
General transcription factor IIH subunit 2
Peptide A accession
Q13889
Peptide B accession
Q13888
Peptide A residue number
142
Peptide B residue number
382

Ligandability

Cysteine 142 of General transcription factor IIH subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 345 and 371.

Details

Redox score ?
90
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
1
% buried
68
Peptide accession
Q13888
Residue number A
345
Residue number B
371
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 345 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 371 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 291 and 294.

Details

Redox score ?
89
PDB code
6ro4
Structure name
structure of the core tfiih-xpa-dna complex
Structure deposition date
2019-05-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
3
Peptide accession
Q13888
Residue number A
291
Residue number B
294
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 291 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 294 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 345 and 368.

Details

Redox score ?
88
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
1
% buried
52
Peptide accession
Q13888
Residue number A
345
Residue number B
368
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 345 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 368 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 291 and 308.

Details

Redox score ?
86
PDB code
6ro4
Structure name
structure of the core tfiih-xpa-dna complex
Structure deposition date
2019-05-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
3
Peptide accession
Q13888
Residue number A
291
Residue number B
308
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 291 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 294 and 305.

Details

Redox score ?
86
PDB code
6ro4
Structure name
structure of the core tfiih-xpa-dna complex
Structure deposition date
2019-05-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
2
Peptide accession
Q13888
Residue number A
294
Residue number B
305
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 294 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 360 and 363.

Details

Redox score ?
81
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
22
Peptide accession
Q13888
Residue number A
360
Residue number B
363
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 360 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 363 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 360 and 385.

Details

Redox score ?
81
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
14
Peptide accession
Q13888
Residue number A
360
Residue number B
385
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 360 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 345 and 348.

Details

Redox score ?
80
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
5
% buried
nan
Peptide accession
Q13888
Residue number A
345
Residue number B
348
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 345 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 348 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 348 and 371.

Details

Redox score ?
79
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
5
% buried
76
Peptide accession
Q13888
Residue number A
348
Residue number B
371
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 348 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 371 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 291 and 305.

Details

Redox score ?
79
PDB code
7nvw
Structure name
tfiih in a pre-translocated state (without adp-bef3)
Structure deposition date
2021-03-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
6
% buried
84
Peptide accession
Q13888
Residue number A
291
Residue number B
305
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 291 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 360 and 382.

Details

Redox score ?
77
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
28
Peptide accession
Q13888
Residue number A
360
Residue number B
382
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 360 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 348 and 368.

Details

Redox score ?
73
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
46
Peptide accession
Q13888
Residue number A
348
Residue number B
368
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 348 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 368 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 363 and 385.

Details

Redox score ?
70
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
24
Peptide accession
Q13888
Residue number A
363
Residue number B
385
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 363 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 363 and 382.

Details

Redox score ?
70
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
38
Peptide accession
Q13888
Residue number A
363
Residue number B
382
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 363 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 382 and 385.

Details

Redox score ?
67
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
43
Peptide accession
Q13888
Residue number A
382
Residue number B
385
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 382 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 177 and 208.

Details

Redox score ?
67
PDB code
6o9l
Structure name
human holo-pic in the closed state
Structure deposition date
2019-03-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
9
% buried
100
Peptide accession
Q13888
Residue number A
177
Residue number B
208
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 177 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 368 and 371.

Details

Redox score ?
62
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
68
Peptide accession
Q13888
Residue number A
368
Residue number B
371
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 368 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 371 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 294 and 308.

Details

Redox score ?
61
PDB code
7nvx
Structure name
tfiih in a post-translocated state (with adp-bef3)
Structure deposition date
2021-03-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
16
% buried
nan
Peptide accession
Q13888
Residue number A
294
Residue number B
308
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 294 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 305 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7nw0
Structure name
rna polymerase ii pre-initiation complex with open promoter dna
Structure deposition date
2021-03-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
16
% buried
82
Peptide accession
Q13888
Residue number A
305
Residue number B
308
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 305 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 345 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5o85
Structure name
p34-p44 complex
Structure deposition date
2017-06-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
1
% buried
58
Peptide accession
Q13888
Residue number A
345
Residue number B
382
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 345 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 381 and 385. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6o9m
Structure name
structure of the human apo tfiih
Structure deposition date
2019-03-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
77
Peptide accession
Q13888
Residue number A
381
Residue number B
385
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 381 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 360 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6o9l
Structure name
human holo-pic in the closed state
Structure deposition date
2019-03-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
67
Peptide accession
Q13888
Residue number A
360
Residue number B
381
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 360 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 381 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7nvz
Structure name
rna polymerase ii pre-initiation complex with closed promoter dna in distal position
Structure deposition date
2021-03-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
11
% buried
84
Peptide accession
Q13888
Residue number A
381
Residue number B
382
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 381 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 363 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7nvy
Structure name
rna polymerase ii pre-initiation complex with closed promoter dna in proximal position
Structure deposition date
2021-03-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
68
Peptide accession
Q13888
Residue number A
363
Residue number B
381
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 363 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 299 and 305. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6o9m
Structure name
structure of the human apo tfiih
Structure deposition date
2019-03-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
58
Peptide accession
Q13888
Residue number A
299
Residue number B
305
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 299 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription factor IIH subunit 2 between cysteines 371 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
7nvz
Structure name
rna polymerase ii pre-initiation complex with closed promoter dna in distal position
Structure deposition date
2021-03-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
14
% buried
84
Peptide accession
Q13888
Residue number A
371
Residue number B
382
Peptide name
General transcription factor IIH subunit 2

Ligandability

Cysteine 371 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of General transcription factor IIH subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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