ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras-specific guanine nucleotide-releasing factor 1

Intramolecular
Cysteine 1171 and cysteine 1175
Cysteine 1109 and cysteine 1111
A redox-regulated disulphide may form within Ras-specific guanine nucleotide-releasing factor 1 between cysteines 1171 and 1175.

Details

Redox score ?
77
PDB code
2ije
Structure name
crystal structure of the cdc25 domain of rasgrf1
Structure deposition date
2006-09-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
62
Peptide accession
P27671
Residue number A
1171
Residue number B
1175
Peptide name
Ras-specific guanine nucleotide-releasing factor 1

Ligandability

Cysteine 1171 of Ras-specific guanine nucleotide-releasing factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1175 of Ras-specific guanine nucleotide-releasing factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ras-specific guanine nucleotide-releasing factor 1 between cysteines 1109 and 1111. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2ije
Structure name
crystal structure of the cdc25 domain of rasgrf1
Structure deposition date
2006-09-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
60
Peptide accession
P27671
Residue number A
1109
Residue number B
1111
Peptide name
Ras-specific guanine nucleotide-releasing factor 1

Ligandability

Cysteine 1109 of Ras-specific guanine nucleotide-releasing factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1111 of Ras-specific guanine nucleotide-releasing factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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