ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cyclic nucleotide-gated cation channel beta-1

Intramolecular
Cysteine 671 and cysteine 766
Cysteine 807 and cysteine 835
A redox-regulated disulphide may form within Cyclic nucleotide-gated cation channel beta-1 between cysteines 671 and 766.

Details

Redox score ?
70
PDB code
7rh9
Structure name
cryo-em structure of human rod cnga1/b1 channel in apo state
Structure deposition date
2021-07-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
80
Peptide accession
Q14028
Residue number A
671
Residue number B
766
Peptide name
Cyclic nucleotide-gated cation channel beta-1

Ligandability

Cysteine 671 of Cyclic nucleotide-gated cation channel beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 766 of Cyclic nucleotide-gated cation channel beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cyclic nucleotide-gated cation channel beta-1 between cysteines 807 and 835. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7rhg
Structure name
cryo-em structure of human rod cnga1/b1 channel in camp-bound state
Structure deposition date
2021-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
86
Peptide accession
Q14028
Residue number A
807
Residue number B
835
Peptide name
Cyclic nucleotide-gated cation channel beta-1

Ligandability

Cysteine 807 of Cyclic nucleotide-gated cation channel beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 835 of Cyclic nucleotide-gated cation channel beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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