ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Lysosome membrane protein 2

Intramolecular
Cysteine 274 and cysteine 329
Cysteine 312 and cysteine 318
Cysteine 245 and cysteine 312
Cysteine 245 and cysteine 318
A redox-regulated disulphide may form within Lysosome membrane protein 2 between cysteines 274 and 329.

Details

Redox score ?
83
PDB code
4f7b
Structure name
structure of the lysosomal domain of limp-2
Structure deposition date
2012-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14108
Residue number A
274
Residue number B
329
Peptide name
Lysosome membrane protein 2

Ligandability

Cysteine 274 of Lysosome membrane protein 2

Cysteine 329 of Lysosome membrane protein 2

A redox-regulated disulphide may form within Lysosome membrane protein 2 between cysteines 312 and 318.

Details

Redox score ?
77
PDB code
5xbm
Structure name
structure of scarb2-jl2 complex
Structure deposition date
2017-03-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
45
Peptide accession
Q14108
Residue number A
312
Residue number B
318
Peptide name
Lysosome membrane protein 2

Ligandability

Cysteine 312 of Lysosome membrane protein 2

Cysteine 318 of Lysosome membrane protein 2

A redox-regulated disulphide may form within Lysosome membrane protein 2 between cysteines 245 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4f7b
Structure name
structure of the lysosomal domain of limp-2
Structure deposition date
2012-05-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
nan
Peptide accession
Q14108
Residue number A
245
Residue number B
312
Peptide name
Lysosome membrane protein 2

Ligandability

Cysteine 245 of Lysosome membrane protein 2

Cysteine 312 of Lysosome membrane protein 2

A redox-regulated disulphide may form within Lysosome membrane protein 2 between cysteines 245 and 318. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4q4b
Structure name
crystal structure of limp-2 (space group c2221)
Structure deposition date
2014-04-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
nan
Peptide accession
Q14108
Residue number A
245
Residue number B
318
Peptide name
Lysosome membrane protein 2

Ligandability

Cysteine 245 of Lysosome membrane protein 2

Cysteine 318 of Lysosome membrane protein 2

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