ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Interleukin-18

Intermolecular
Cysteine 104 and cysteine 104
Intramolecular
Cysteine 74 and cysteine 104 L
A redox-regulated disulphide may form between two units of Interleukin-18 at cysteines 104 and 104 (68 and 68 respectively in this structure).

Details

Redox score ?
72
PDB code
4xft
Structure name
structure of il-18 ser mutant iii
Structure deposition date
2014-12-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
38
Peptide A name
Interleukin-18
Peptide B name
Interleukin-18
Peptide A accession
Q14116
Peptide B accession
Q14116
Peptide A residue number
104
Peptide B residue number
104

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-18 between cysteines 74 and 104 (38 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1j0s
Structure name
solution structure of the human interleukin-18
Structure deposition date
2002-11-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
31
Minimum pKa ?
9
% buried
0
Peptide accession
Q14116
Residue number A
74
Residue number B
104
Peptide name
Interleukin-18

Ligandability

Cysteine 74 of Interleukin-18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Interleukin-18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: