ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dihydropyrimidinase

Intramolecular
Cysteine 182 and cysteine 242
Cysteine 126 and cysteine 127
A redox-regulated disulphide may form within Dihydropyrimidinase between cysteines 182 and 242.

Details

Redox score ?
61
PDB code
2vr2
Structure name
human dihydropyrimidinase
Structure deposition date
2008-03-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
100
Peptide accession
Q14117
Residue number A
182
Residue number B
242
Peptide name
Dihydropyrimidinase

Ligandability

Cysteine 182 of Dihydropyrimidinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Dihydropyrimidinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase between cysteines 126 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2vr2
Structure name
human dihydropyrimidinase
Structure deposition date
2008-03-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
11
% buried
80
Peptide accession
Q14117
Residue number A
126
Residue number B
127
Peptide name
Dihydropyrimidinase

Ligandability

Cysteine 126 of Dihydropyrimidinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Dihydropyrimidinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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