ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Tripartite motif-containing protein 29

Intramolecular
Cysteine 225 and cysteine 247
Cysteine 225 and cysteine 244
Cysteine 244 and cysteine 247
Cysteine 225 and cysteine 242
Cysteine 236 and cysteine 247
Cysteine 236 and cysteine 242
Cysteine 242 and cysteine 247
Cysteine 242 and cysteine 244
A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 225 and 247 (21 and 43 respectively in this structure).

Details

Redox score ?
88
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
5
% buried
2
Peptide accession
Q14134
Residue number A
225
Residue number B
247
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 225 of Tripartite motif-containing protein 29

Cysteine 247 of Tripartite motif-containing protein 29

A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 225 and 244 (21 and 40 respectively in this structure).

Details

Redox score ?
86
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
5
% buried
0
Peptide accession
Q14134
Residue number A
225
Residue number B
244
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 225 of Tripartite motif-containing protein 29

Cysteine 244 of Tripartite motif-containing protein 29

A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 244 and 247 (40 and 43 respectively in this structure).

Details

Redox score ?
77
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
2
Peptide accession
Q14134
Residue number A
244
Residue number B
247
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 244 of Tripartite motif-containing protein 29

Cysteine 247 of Tripartite motif-containing protein 29

A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 225 and 242 (21 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
5
% buried
6
Peptide accession
Q14134
Residue number A
225
Residue number B
242
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 225 of Tripartite motif-containing protein 29

Cysteine 242 of Tripartite motif-containing protein 29

A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 236 and 247 (32 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
2
Peptide accession
Q14134
Residue number A
236
Residue number B
247
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 236 of Tripartite motif-containing protein 29

Cysteine 247 of Tripartite motif-containing protein 29

A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 236 and 242 (32 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
6
Peptide accession
Q14134
Residue number A
236
Residue number B
242
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 236 of Tripartite motif-containing protein 29

Cysteine 242 of Tripartite motif-containing protein 29

A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 242 and 247 (38 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
8
Peptide accession
Q14134
Residue number A
242
Residue number B
247
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 242 of Tripartite motif-containing protein 29

Cysteine 247 of Tripartite motif-containing protein 29

A redox-regulated disulphide may form within Tripartite motif-containing protein 29 between cysteines 242 and 244 (38 and 40 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2csv
Structure name
solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha
Structure deposition date
2005-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
6
Peptide accession
Q14134
Residue number A
242
Residue number B
244
Peptide name
Tripartite motif-containing protein 29

Ligandability

Cysteine 242 of Tripartite motif-containing protein 29

Cysteine 244 of Tripartite motif-containing protein 29

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