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a tool for identifying drug-targetable redox-active disulphides

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MORC family CW-type zinc finger protein 3

Intermolecular
Cysteine 446 and cysteine 446
Cysteine 413 and cysteine 446 L
Cysteine 446 and cysteine 416 L
Cysteine 446 and cysteine 435
Cysteine 413 and cysteine 416 L
Cysteine 413 and cysteine 413 L
Cysteine 416 and cysteine 416 L
Intramolecular
Cysteine 413 and cysteine 446 L
Cysteine 413 and cysteine 416 L
Cysteine 416 and cysteine 446 L
More...
Cysteine 435 and cysteine 446
Cysteine 416 and cysteine 435 L
Cysteine 413 and cysteine 435 L
A redox-regulated disulphide may form between two units of MORC family CW-type zinc finger protein 3 at cysteines 446 and 446.

Details

Redox score ?
72
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
MORC family CW-type zinc finger protein 3
Peptide B name
MORC family CW-type zinc finger protein 3
Peptide A accession
Q14149
Peptide B accession
Q14149
Peptide A residue number
446
Peptide B residue number
446

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MORC family CW-type zinc finger protein 3 at cysteines 413 and 446.

Details

Redox score ?
61
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
MORC family CW-type zinc finger protein 3
Peptide B name
MORC family CW-type zinc finger protein 3
Peptide A accession
Q14149
Peptide B accession
Q14149
Peptide A residue number
413
Peptide B residue number
446

Ligandability

Cysteine 413 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 446 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MORC family CW-type zinc finger protein 3 at cysteines 446 and 416. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
MORC family CW-type zinc finger protein 3
Peptide B name
MORC family CW-type zinc finger protein 3
Peptide A accession
Q14149
Peptide B accession
Q14149
Peptide A residue number
446
Peptide B residue number
416

Ligandability

Cysteine 446 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MORC family CW-type zinc finger protein 3 at cysteines 446 and 435. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
MORC family CW-type zinc finger protein 3
Peptide B name
MORC family CW-type zinc finger protein 3
Peptide A accession
Q14149
Peptide B accession
Q14149
Peptide A residue number
446
Peptide B residue number
435

Ligandability

Cysteine 446 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 435 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MORC family CW-type zinc finger protein 3 at cysteines 413 and 416. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
MORC family CW-type zinc finger protein 3
Peptide B name
MORC family CW-type zinc finger protein 3
Peptide A accession
Q14149
Peptide B accession
Q14149
Peptide A residue number
413
Peptide B residue number
416

Ligandability

Cysteine 413 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 416 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MORC family CW-type zinc finger protein 3 at cysteines 413 and 413. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
MORC family CW-type zinc finger protein 3
Peptide B name
MORC family CW-type zinc finger protein 3
Peptide A accession
Q14149
Peptide B accession
Q14149
Peptide A residue number
413
Peptide B residue number
413

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MORC family CW-type zinc finger protein 3 at cysteines 416 and 416. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide A name
MORC family CW-type zinc finger protein 3
Peptide B name
MORC family CW-type zinc finger protein 3
Peptide A accession
Q14149
Peptide B accession
Q14149
Peptide A residue number
416
Peptide B residue number
416

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 3 between cysteines 413 and 446.

Details

Redox score ?
88
PDB code
5ix1
Structure name
crystal structure of mouse morc3 atpase-cw cassette in complex with amppnp and h3k4me3 peptide
Structure deposition date
2016-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
9
Peptide accession
F7BJB9
Residue number A
413
Residue number B
446
Peptide name
MORC family CW-type zinc finger protein 3

Ligandability

Cysteine 413 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 446 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 3 between cysteines 413 and 416.

Details

Redox score ?
87
PDB code
5ix1
Structure name
crystal structure of mouse morc3 atpase-cw cassette in complex with amppnp and h3k4me3 peptide
Structure deposition date
2016-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
14
Peptide accession
F7BJB9
Residue number A
413
Residue number B
416
Peptide name
MORC family CW-type zinc finger protein 3

Ligandability

Cysteine 413 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 416 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 3 between cysteines 416 and 446.

Details

Redox score ?
85
PDB code
5ix2
Structure name
crystal structure of mouse morc3 atpase-cw cassette in complex with amppnp and unmodified h3 peptide
Structure deposition date
2016-03-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
4
Peptide accession
F7BJB9
Residue number A
416
Residue number B
446
Peptide name
MORC family CW-type zinc finger protein 3

Ligandability

Cysteine 416 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 446 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 3 between cysteines 435 and 446.

Details

Redox score ?
83
PDB code
5ix2
Structure name
crystal structure of mouse morc3 atpase-cw cassette in complex with amppnp and unmodified h3 peptide
Structure deposition date
2016-03-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
16
Peptide accession
F7BJB9
Residue number A
435
Residue number B
446
Peptide name
MORC family CW-type zinc finger protein 3

Ligandability

Cysteine 435 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 446 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 3 between cysteines 416 and 435.

Details

Redox score ?
81
PDB code
5ix1
Structure name
crystal structure of mouse morc3 atpase-cw cassette in complex with amppnp and h3k4me3 peptide
Structure deposition date
2016-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
18
Peptide accession
F7BJB9
Residue number A
416
Residue number B
435
Peptide name
MORC family CW-type zinc finger protein 3

Ligandability

Cysteine 416 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 435 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 3 between cysteines 413 and 435.

Details

Redox score ?
73
PDB code
4qq4
Structure name
cw-type zinc finger of morc3 in complex with the amino terminus of histone h3
Structure deposition date
2014-06-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14149
Residue number A
413
Residue number B
435
Peptide name
MORC family CW-type zinc finger protein 3

Ligandability

Cysteine 413 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 435 of MORC family CW-type zinc finger protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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