Rho guanine nucleotide exchange factor 7
Intramolecular
Cysteine 365 and cysteine 448
Cysteine 336 and cysteine 349
Cysteine 42 and cysteine 66
Cysteine 42 and cysteine 77
1by1 A 107 A 190
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 7 between cysteines 365 and 448 (107 and 190 respectively in this structure).
Details
Redox score ?
76
PDB code
1by1
Structure name
dbl homology domain from beta-pix
Structure deposition date
1998-10-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
33
Peptide accession
Q14155
Residue number A
365
Residue number B
448
Peptide name
Rho guanine nucleotide exchange factor 7
Ligandability
Cysteine 365 of Rho guanine nucleotide exchange factor 7
Cysteine 448 of Rho guanine nucleotide exchange factor 7
1by1 A 78 A 91
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 7 between cysteines 336 and 349 (78 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
1by1
Structure name
dbl homology domain from beta-pix
Structure deposition date
1998-10-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
20
Peptide accession
Q14155
Residue number A
336
Residue number B
349
Peptide name
Rho guanine nucleotide exchange factor 7
Ligandability
Cysteine 336 of Rho guanine nucleotide exchange factor 7
Cysteine 349 of Rho guanine nucleotide exchange factor 7
2l3g A 52 A 76
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 7 between cysteines 42 and 66 (52 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
2l3g
Structure name
solution nmr structure of ch domain of rho guanine nucleotide exchange factor 7 from homo sapiens, northeast structural genomics consortium target hr4495e
Structure deposition date
2010-09-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
40
Peptide accession
Q14155
Residue number A
42
Residue number B
66
Peptide name
Rho guanine nucleotide exchange factor 7
Ligandability
Cysteine 42 of Rho guanine nucleotide exchange factor 7
Cysteine 66 of Rho guanine nucleotide exchange factor 7
2l3g A 52 A 87
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 7 between cysteines 42 and 77 (52 and 87 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
2l3g
Structure name
solution nmr structure of ch domain of rho guanine nucleotide exchange factor 7 from homo sapiens, northeast structural genomics consortium target hr4495e
Structure deposition date
2010-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
68
Peptide accession
Q14155
Residue number A
42
Residue number B
77
Peptide name
Rho guanine nucleotide exchange factor 7
Ligandability
Cysteine 42 of Rho guanine nucleotide exchange factor 7
Cysteine 77 of Rho guanine nucleotide exchange factor 7
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