DNA polymerase alpha subunit B
Intermolecular
Cysteine 1281 of DNA polymerase alpha catalytic subunit and cysteine 392 L
Intramolecular
Cysteine 554 and cysteine 556
Cysteine 19 and cysteine 49
Cysteine 198 and cysteine 460 L
Cysteine 554 and cysteine 590
5exr G 1281 H 392
A redox-regulated disulphide may form between cysteine 1281 of DNA polymerase alpha catalytic subunit and cysteine 392 of DNA polymerase alpha subunit B.
Details
Redox score ?
71
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
74
Peptide A name
DNA polymerase alpha catalytic subunit
Peptide B name
DNA polymerase alpha subunit B
Peptide A accession
P09884
Peptide B accession
Q14181
Peptide A residue number
1281
Peptide B residue number
392
Ligandability
Cysteine 1281 of DNA polymerase alpha catalytic subunit
Cysteine 392 of DNA polymerase alpha subunit B
5exr H 554 H 556
A redox-regulated disulphide may form within DNA polymerase alpha subunit B between cysteines 554 and 556.
Details
Redox score ?
69
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
100
Peptide accession
Q14181
Residue number A
554
Residue number B
556
Peptide name
DNA polymerase alpha subunit B
Ligandability
Cysteine 554 of DNA polymerase alpha subunit B
Cysteine 556 of DNA polymerase alpha subunit B
4e2i 8 19 8 49
A redox-regulated disulphide may form within DNA polymerase alpha subunit B between cysteines 19 and 49. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4e2i
Structure name
the complex structure of the sv40 helicase large t antigen and p68 subunit of dna polymerase alpha-primase
Structure deposition date
2012-03-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
46
Peptide accession
Q14181
Residue number A
19
Residue number B
49
Peptide name
DNA polymerase alpha subunit B
Ligandability
Cysteine 19 of DNA polymerase alpha subunit B
Cysteine 49 of DNA polymerase alpha subunit B
5exr H 198 H 460
A redox-regulated disulphide may form within DNA polymerase alpha subunit B between cysteines 198 and 460. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
78
Peptide accession
Q14181
Residue number A
198
Residue number B
460
Peptide name
DNA polymerase alpha subunit B
Ligandability
Cysteine 198 of DNA polymerase alpha subunit B
Cysteine 460 of DNA polymerase alpha subunit B
5exr H 554 H 590
A redox-regulated disulphide may form within DNA polymerase alpha subunit B between cysteines 554 and 590. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
99
Peptide accession
Q14181
Residue number A
554
Residue number B
590
Peptide name
DNA polymerase alpha subunit B
Ligandability
Cysteine 554 of DNA polymerase alpha subunit B
Cysteine 590 of DNA polymerase alpha subunit B
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