ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription factor Dp-1

Intermolecular
Cysteine 274 and cysteine 274
Intramolecular
Cysteine 307 and cysteine 314
A redox-regulated disulphide may form between two units of Transcription factor Dp-1 at cysteines 274 and 274. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5tuv
Structure name
crystal structure of the e2f5-dp1-p107 ternary complex
Structure deposition date
2016-11-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
13
% buried
100
Peptide A name
Transcription factor Dp-1
Peptide B name
Transcription factor Dp-1
Peptide A accession
Q14186
Peptide B accession
Q14186
Peptide A residue number
274
Peptide B residue number
274

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription factor Dp-1 between cysteines 307 and 314.

Details

Redox score ?
64
PDB code
5tuu
Structure name
crystal structure of the e2f4-dp1 coiled coil and marked-box domains
Structure deposition date
2016-11-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
24
Peptide accession
Q14186
Residue number A
307
Residue number B
314
Peptide name
Transcription factor Dp-1

Ligandability

Cysteine 307 of Transcription factor Dp-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Transcription factor Dp-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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