ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Intramolecular
Cysteine 103 and cysteine 109
A redox-regulated disulphide may form within Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN between cysteines 103 and 109.

Details

Redox score ?
66
PDB code
2fby
Structure name
wrn exonuclease, eu complex
Structure deposition date
2005-12-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14191
Residue number A
103
Residue number B
109
Peptide name
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Ligandability

Cysteine 103 of Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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