a tool for identifying drug-targetable redox-active disulphides

Translation initiation factor eIF-2B subunit alpha

Intermolecular

Cysteine 218 and cysteine 218 L

A redox-regulated disulphide may form between two units of Translation initiation factor eIF-2B subunit alpha at cysteines 218 and 218. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

51

PDB code

Structure name

crystal structure of eif2balpha with a ligand

Structure deposition date

2020-11-02

Thiol separation (Å)

5

Half-sphere exposure sum ?

83

Minimum pK_a ?

12

% buried

100

Peptide A name

Translation initiation factor eIF-2B subunit alpha

Peptide B name

Translation initiation factor eIF-2B subunit alpha

Peptide A accession

Peptide B accession

Peptide A residue number

218

Peptide B residue number

218

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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