ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Frizzled-2

Intramolecular
Cysteine 114 and cysteine 138
Cysteine 39 and cysteine 100
Cysteine 84 and cysteine 121
Cysteine 47 and cysteine 93
Cysteine 110 and cysteine 150
A redox-regulated disulphide may form within Frizzled-2 between cysteines 114 and 138.

Details

Redox score ?
85
PDB code
6c0b
Structure name
structural basis for recognition of frizzled proteins by clostridium difficile toxin b
Structure deposition date
2017-12-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14332
Residue number A
114
Residue number B
138
Peptide name
Frizzled-2

Ligandability

Cysteine 114 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Frizzled-2 between cysteines 39 and 100.

Details

Redox score ?
85
PDB code
7x8p
Structure name
frizzled 2 crd in complex with pf7_a5 fab
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14332
Residue number A
39
Residue number B
100
Peptide name
Frizzled-2

Ligandability

Cysteine 39 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Frizzled-2 between cysteines 84 and 121.

Details

Redox score ?
85
PDB code
7x8p
Structure name
frizzled 2 crd in complex with pf7_a5 fab
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14332
Residue number A
84
Residue number B
121
Peptide name
Frizzled-2

Ligandability

Cysteine 84 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Frizzled-2 between cysteines 47 and 93.

Details

Redox score ?
82
PDB code
7x8p
Structure name
frizzled 2 crd in complex with pf7_a5 fab
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14332
Residue number A
47
Residue number B
93
Peptide name
Frizzled-2

Ligandability

Cysteine 47 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Frizzled-2 between cysteines 110 and 150.

Details

Redox score ?
79
PDB code
7x8p
Structure name
frizzled 2 crd in complex with pf7_a5 fab
Structure deposition date
2022-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14332
Residue number A
110
Residue number B
150
Peptide name
Frizzled-2

Ligandability

Cysteine 110 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Frizzled-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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