ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transforming growth factor beta activator LRRC32

Intramolecular
Cysteine 26 and cysteine 35
Cysteine 425 and cysteine 436
Cysteine 342 and cysteine 364
A redox-regulated disulphide may form within Transforming growth factor beta activator LRRC32 between cysteines 26 and 35.

Details

Redox score ?
86
PDB code
6gff
Structure name
structure of garp (lrrc32) in complex with latent tgf-beta1 and mhg-8 fab
Structure deposition date
2018-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14392
Residue number A
26
Residue number B
35
Peptide name
Transforming growth factor beta activator LRRC32

Ligandability

Cysteine 26 of Transforming growth factor beta activator LRRC32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 35 of Transforming growth factor beta activator LRRC32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transforming growth factor beta activator LRRC32 between cysteines 425 and 436.

Details

Redox score ?
82
PDB code
6gff
Structure name
structure of garp (lrrc32) in complex with latent tgf-beta1 and mhg-8 fab
Structure deposition date
2018-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14392
Residue number A
425
Residue number B
436
Peptide name
Transforming growth factor beta activator LRRC32

Ligandability

Cysteine 425 of Transforming growth factor beta activator LRRC32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 436 of Transforming growth factor beta activator LRRC32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transforming growth factor beta activator LRRC32 between cysteines 342 and 364.

Details

Redox score ?
60
PDB code
6gff
Structure name
structure of garp (lrrc32) in complex with latent tgf-beta1 and mhg-8 fab
Structure deposition date
2018-04-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
4
Peptide accession
Q14392
Residue number A
342
Residue number B
364
Peptide name
Transforming growth factor beta activator LRRC32

Ligandability

Cysteine 342 of Transforming growth factor beta activator LRRC32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of Transforming growth factor beta activator LRRC32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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