ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Growth arrest-specific protein 6

Intramolecular
Cysteine 262 and cysteine 277
Cysteine 283 and cysteine 570
Cysteine 643 and cysteine 670
Cysteine 444 and cysteine 470
A redox-regulated disulphide may form within Growth arrest-specific protein 6 between cysteines 262 and 277.

Details

Redox score ?
86
PDB code
1h30
Structure name
c-terminal lg domain pair of human gas6
Structure deposition date
2002-08-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14393
Residue number A
262
Residue number B
277
Peptide name
Growth arrest-specific protein 6

Ligandability

Cysteine 262 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest-specific protein 6 between cysteines 283 and 570.

Details

Redox score ?
83
PDB code
1h30
Structure name
c-terminal lg domain pair of human gas6
Structure deposition date
2002-08-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14393
Residue number A
283
Residue number B
570
Peptide name
Growth arrest-specific protein 6

Ligandability

Cysteine 283 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 570 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest-specific protein 6 between cysteines 643 and 670.

Details

Redox score ?
80
PDB code
1h30
Structure name
c-terminal lg domain pair of human gas6
Structure deposition date
2002-08-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14393
Residue number A
643
Residue number B
670
Peptide name
Growth arrest-specific protein 6

Ligandability

Cysteine 643 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 670 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 1 of Growth arrest-specific protein 6 between cysteines 444 and 470.

Details

Redox score ?
79
PDB code
4ra0
Structure name
an engineered axl 'decoy receptor' effectively silences the gas6-axl signaling axis
Structure deposition date
2014-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14393-2
Residue number A
444
Residue number B
470
Peptide name
Isoform 1 of Growth arrest-specific protein 6

Ligandability

Cysteine 444 of Isoform 1 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 470 of Isoform 1 of Growth arrest-specific protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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