Metabotropic glutamate receptor 2
Intermolecular
Cysteine 121 and cysteine 121
Intramolecular
Cysteine 525 and cysteine 537
Cysteine 504 and cysteine 522
Cysteine 540 and cysteine 553
Cysteine 400 and cysteine 407
Cysteine 500 and cysteine 519
Cysteine 50 and cysteine 92
Cysteine 632 and cysteine 721
Cysteine 355 and cysteine 362
Cysteine 234 and cysteine 518
More...Cysteine 518 and cysteine 519
Cysteine 576 and cysteine 795
Cysteine 500 and cysteine 518
Cysteine 234 and cysteine 519
Cysteine 234 and cysteine 500
Cysteine 537 and cysteine 540
Cysteine 504 and cysteine 525
Cysteine 504 and cysteine 537
Cysteine 770 and cysteine 808
Cysteine 525 and cysteine 540
Cysteine 616 and cysteine 646
Cysteine 742 and cysteine 808
Cysteine 742 and cysteine 770
Cysteine 519 and cysteine 522
Cysteine 576 and cysteine 618
Cysteine 616 and cysteine 618
Cysteine 646 and cysteine 683
Cysteine 646 and cysteine 808
7epa A 121 B 121
A redox-regulated disulphide may form between two units of Metabotropic glutamate receptor 2 at cysteines 121 and 121.
Details
Redox score ?
88
PDB code
7epa
Structure name
cryo-em structure of inactive mglu2 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide A name
Metabotropic glutamate receptor 2
Peptide B name
Metabotropic glutamate receptor 2
Peptide A accession
Q14416
Peptide B accession
Q14416
Peptide A residue number
121
Peptide B residue number
121
Ligandability
5kzn A 525 A 537
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 525 and 537.
Details
Redox score ?
89
PDB code
5kzn
Structure name
metabotropic glutamate receptor
Structure deposition date
2016-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
525
Residue number B
537
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 525 of Metabotropic glutamate receptor 2
Cysteine 537 of Metabotropic glutamate receptor 2
5kzq A 504 A 522
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 504 and 522.
Details
Redox score ?
88
PDB code
5kzq
Structure name
metabotropic glutamate receptor in complex with antagonist (1~{s}, 2~{r},3~{s},4~{s},5~{r},6~{r})-2-azanyl-3-[[3,4-bis(fluoranyl) phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3
Structure deposition date
2016-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
504
Residue number B
522
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 504 of Metabotropic glutamate receptor 2
Cysteine 522 of Metabotropic glutamate receptor 2
7mts A 540 A 553
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 540 and 553.
Details
Redox score ?
88
PDB code
7mts
Structure name
cryoem structure of mglu2 - gi complex
Structure deposition date
2021-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
540
Residue number B
553
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 540 of Metabotropic glutamate receptor 2
Cysteine 553 of Metabotropic glutamate receptor 2
4xaq A 400 A 407
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 400 and 407.
Details
Redox score ?
87
PDB code
4xaq
Structure name
mglur2 ecd and mglur3 ecd with ligands
Structure deposition date
2014-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
400
Residue number B
407
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 400 of Metabotropic glutamate receptor 2
Cysteine 407 of Metabotropic glutamate receptor 2
5kzq A 500 A 519
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 500 and 519.
Details
Redox score ?
85
PDB code
5kzq
Structure name
metabotropic glutamate receptor in complex with antagonist (1~{s}, 2~{r},3~{s},4~{s},5~{r},6~{r})-2-azanyl-3-[[3,4-bis(fluoranyl) phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3
Structure deposition date
2016-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
500
Residue number B
519
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 500 of Metabotropic glutamate receptor 2
Cysteine 519 of Metabotropic glutamate receptor 2
7mtr A 50 A 92
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 50 and 92.
Details
Redox score ?
78
PDB code
7mtr
Structure name
cryoem structure of full-length mglu2 bound to ago-pam adx55164 and glutamate
Structure deposition date
2021-05-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
40
Peptide accession
Q14416
Residue number A
50
Residue number B
92
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 50 of Metabotropic glutamate receptor 2
Cysteine 92 of Metabotropic glutamate receptor 2
7mts B 632 B 721
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 632 and 721.
Details
Redox score ?
75
PDB code
7mts
Structure name
cryoem structure of mglu2 - gi complex
Structure deposition date
2021-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
34
Peptide accession
Q14416
Residue number A
632
Residue number B
721
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 632 of Metabotropic glutamate receptor 2
Cysteine 721 of Metabotropic glutamate receptor 2
7mtr B 355 B 362
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 355 and 362.
Details
Redox score ?
74
PDB code
7mtr
Structure name
cryoem structure of full-length mglu2 bound to ago-pam adx55164 and glutamate
Structure deposition date
2021-05-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
37
Minimum pKa ?
10
% buried
0
Peptide accession
Q14416
Residue number A
355
Residue number B
362
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 355 of Metabotropic glutamate receptor 2
Cysteine 362 of Metabotropic glutamate receptor 2
5kzq A 234 A 518
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 234 and 518.
Details
Redox score ?
71
PDB code
5kzq
Structure name
metabotropic glutamate receptor in complex with antagonist (1~{s}, 2~{r},3~{s},4~{s},5~{r},6~{r})-2-azanyl-3-[[3,4-bis(fluoranyl) phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3
Structure deposition date
2016-07-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
23
Peptide accession
Q14416
Residue number A
234
Residue number B
518
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 234 of Metabotropic glutamate receptor 2
Cysteine 518 of Metabotropic glutamate receptor 2
5kzn A 518 A 519
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 518 and 519. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
5kzn
Structure name
metabotropic glutamate receptor
Structure deposition date
2016-07-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
518
Residue number B
519
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 518 of Metabotropic glutamate receptor 2
Cysteine 519 of Metabotropic glutamate receptor 2
7epb B 576 B 795
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 576 and 795. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7epb
Structure name
cryo-em structure of ly354740-bound mglu2 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
15
Peptide accession
Q14416
Residue number A
576
Residue number B
795
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 576 of Metabotropic glutamate receptor 2
Cysteine 795 of Metabotropic glutamate receptor 2
5kzn A 500 A 518
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 500 and 518. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5kzn
Structure name
metabotropic glutamate receptor
Structure deposition date
2016-07-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
500
Residue number B
518
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 500 of Metabotropic glutamate receptor 2
Cysteine 518 of Metabotropic glutamate receptor 2
5kzn A 234 A 519
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 234 and 519. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
5kzn
Structure name
metabotropic glutamate receptor
Structure deposition date
2016-07-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
234
Residue number B
519
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 234 of Metabotropic glutamate receptor 2
Cysteine 519 of Metabotropic glutamate receptor 2
5kzn A 234 A 500
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 234 and 500. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5kzn
Structure name
metabotropic glutamate receptor
Structure deposition date
2016-07-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
234
Residue number B
500
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 234 of Metabotropic glutamate receptor 2
Cysteine 500 of Metabotropic glutamate receptor 2
7epa B 537 B 540
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 537 and 540. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7epa
Structure name
cryo-em structure of inactive mglu2 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
537
Residue number B
540
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 537 of Metabotropic glutamate receptor 2
Cysteine 540 of Metabotropic glutamate receptor 2
5kzq A 504 A 525
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 504 and 525. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5kzq
Structure name
metabotropic glutamate receptor in complex with antagonist (1~{s}, 2~{r},3~{s},4~{s},5~{r},6~{r})-2-azanyl-3-[[3,4-bis(fluoranyl) phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3
Structure deposition date
2016-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
504
Residue number B
525
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 504 of Metabotropic glutamate receptor 2
Cysteine 525 of Metabotropic glutamate receptor 2
7mtr B 504 B 537
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 504 and 537. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7mtr
Structure name
cryoem structure of full-length mglu2 bound to ago-pam adx55164 and glutamate
Structure deposition date
2021-05-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
504
Residue number B
537
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 504 of Metabotropic glutamate receptor 2
Cysteine 537 of Metabotropic glutamate receptor 2
7e9g R 770 R 808
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 770 and 808. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7e9g
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu2
Structure deposition date
2021-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
86
Peptide accession
Q14416
Residue number A
770
Residue number B
808
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 770 of Metabotropic glutamate receptor 2
Cysteine 808 of Metabotropic glutamate receptor 2
5kzn A 525 A 540
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 525 and 540. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5kzn
Structure name
metabotropic glutamate receptor
Structure deposition date
2016-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
45
Minimum pKa ?
10
% buried
nan
Peptide accession
Q14416
Residue number A
525
Residue number B
540
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 525 of Metabotropic glutamate receptor 2
Cysteine 540 of Metabotropic glutamate receptor 2
7epa A 616 A 646
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 616 and 646. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7epa
Structure name
cryo-em structure of inactive mglu2 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
10
% buried
48
Peptide accession
Q14416
Residue number A
616
Residue number B
646
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 616 of Metabotropic glutamate receptor 2
Cysteine 646 of Metabotropic glutamate receptor 2
7e9g R 742 R 808
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 742 and 808. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7e9g
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu2
Structure deposition date
2021-03-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
88
Peptide accession
Q14416
Residue number A
742
Residue number B
808
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 742 of Metabotropic glutamate receptor 2
Cysteine 808 of Metabotropic glutamate receptor 2
7epb A 742 A 770
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 742 and 770. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7epb
Structure name
cryo-em structure of ly354740-bound mglu2 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
21
Peptide accession
Q14416
Residue number A
742
Residue number B
770
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 742 of Metabotropic glutamate receptor 2
Cysteine 770 of Metabotropic glutamate receptor 2
7e9g R 519 R 522
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 519 and 522. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7e9g
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu2
Structure deposition date
2021-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14416
Residue number A
519
Residue number B
522
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 519 of Metabotropic glutamate receptor 2
Cysteine 522 of Metabotropic glutamate receptor 2
7mts B 576 B 618
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 576 and 618. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7mts
Structure name
cryoem structure of mglu2 - gi complex
Structure deposition date
2021-05-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
14
Peptide accession
Q14416
Residue number A
576
Residue number B
618
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 576 of Metabotropic glutamate receptor 2
Cysteine 618 of Metabotropic glutamate receptor 2
7mts A 616 A 618
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 616 and 618. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7mts
Structure name
cryoem structure of mglu2 - gi complex
Structure deposition date
2021-05-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
68
Peptide accession
Q14416
Residue number A
616
Residue number B
618
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 616 of Metabotropic glutamate receptor 2
Cysteine 618 of Metabotropic glutamate receptor 2
7mts A 646 A 683
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 646 and 683. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7mts
Structure name
cryoem structure of mglu2 - gi complex
Structure deposition date
2021-05-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
74
Peptide accession
Q14416
Residue number A
646
Residue number B
683
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 646 of Metabotropic glutamate receptor 2
Cysteine 683 of Metabotropic glutamate receptor 2
7e9g R 646 R 808
A redox-regulated disulphide may form within Metabotropic glutamate receptor 2 between cysteines 646 and 808. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7e9g
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu2
Structure deposition date
2021-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
96
Peptide accession
Q14416
Residue number A
646
Residue number B
808
Peptide name
Metabotropic glutamate receptor 2
Ligandability
Cysteine 646 of Metabotropic glutamate receptor 2
Cysteine 808 of Metabotropic glutamate receptor 2
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