cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A at cysteines 957 and 957. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7l29

Structure name

crystal structure of the catalytic domain of human pde3a bound to amp

Structure deposition date

2020-12-16

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Peptide B name

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Peptide A accession

Q14432

Peptide B accession

Q14432

Peptide A residue number

957

Peptide B residue number

957

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A between cysteines 942 and 945. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7l27

Structure name

crystal structure of the catalytic domain of human pde3a

Structure deposition date

2020-12-16

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Q14432

Residue number A

942

Residue number B

945

Peptide name

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Ligandability

Cysteine 942 of cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 945 of cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A between cysteines 1013 and 1073. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?