Growth factor receptor-bound protein 7
Intermolecular
Cysteine 526 and cysteine 526
Cysteine 527 and cysteine 527
Intramolecular
Cysteine 472 and cysteine 521
Cysteine 526 and cysteine 527
Cysteine 472 and cysteine 527
Cysteine 472 and cysteine 526
4wwq A 526 B 526
A redox-regulated disulphide may form between two units of Growth factor receptor-bound protein 7 at cysteines 526 and 526. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
4wwq
Structure name
apo structure of the grb7 sh2 domain
Structure deposition date
2014-11-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
14
% buried
nan
Peptide A name
Growth factor receptor-bound protein 7
Peptide B name
Growth factor receptor-bound protein 7
Peptide A accession
Q14451
Peptide B accession
Q14451
Peptide A residue number
526
Peptide B residue number
526
Ligandability
4wwq A 527 B 527
A redox-regulated disulphide may form between two units of Growth factor receptor-bound protein 7 at cysteines 527 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
4wwq
Structure name
apo structure of the grb7 sh2 domain
Structure deposition date
2014-11-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
nan
Peptide A name
Growth factor receptor-bound protein 7
Peptide B name
Growth factor receptor-bound protein 7
Peptide A accession
Q14451
Peptide B accession
Q14451
Peptide A residue number
527
Peptide B residue number
527
Ligandability
3pqz C 472 C 521
A redox-regulated disulphide may form within Growth factor receptor-bound protein 7 between cysteines 472 and 521. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
3pqz
Structure name
grb7 sh2 with peptide
Structure deposition date
2010-11-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
36
Peptide accession
Q14451
Residue number A
472
Residue number B
521
Peptide name
Growth factor receptor-bound protein 7
Ligandability
Cysteine 472 of Growth factor receptor-bound protein 7
Cysteine 521 of Growth factor receptor-bound protein 7
2qms B 526 B 527
A redox-regulated disulphide may form within Growth factor receptor-bound protein 7 between cysteines 526 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
2qms
Structure name
crystal structure of a signaling molecule
Structure deposition date
2007-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
50
Peptide accession
Q14451
Residue number A
526
Residue number B
527
Peptide name
Growth factor receptor-bound protein 7
Ligandability
Cysteine 526 of Growth factor receptor-bound protein 7
Cysteine 527 of Growth factor receptor-bound protein 7
4wwq A 472 A 527
A redox-regulated disulphide may form within Growth factor receptor-bound protein 7 between cysteines 472 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4wwq
Structure name
apo structure of the grb7 sh2 domain
Structure deposition date
2014-11-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
56
Peptide accession
Q14451
Residue number A
472
Residue number B
527
Peptide name
Growth factor receptor-bound protein 7
Ligandability
Cysteine 472 of Growth factor receptor-bound protein 7
Cysteine 527 of Growth factor receptor-bound protein 7
2l4k A 60 A 114
A redox-regulated disulphide may form within Growth factor receptor-bound protein 7 between cysteines 472 and 526 (60 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
2l4k
Structure name
water refined solution structure of the human grb7-sh2 domain in complex with the 10 amino acid peptide py1139
Structure deposition date
2010-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
22
Peptide accession
Q14451
Residue number A
472
Residue number B
526
Peptide name
Growth factor receptor-bound protein 7
Ligandability
Cysteine 472 of Growth factor receptor-bound protein 7
Cysteine 526 of Growth factor receptor-bound protein 7
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