ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

RNA-binding protein 39

Intramolecular
Cysteine 454 and cysteine 478 L
Cysteine 425 and cysteine 478 L
A redox-regulated disulphide may form within RNA-binding protein 39 between cysteines 454 and 478 (448 and 472 respectively in this structure).

Details

Redox score ?
70
PDB code
4oz0
Structure name
crystal structure of human caperalpha u2af homology motif (apo-state)
Structure deposition date
2014-02-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
8
% buried
78
Peptide accession
Q14498
Residue number A
454
Residue number B
478
Peptide name
RNA-binding protein 39

Ligandability

Cysteine 454 of RNA-binding protein 39

Cysteine 478 of RNA-binding protein 39

A redox-regulated disulphide may form within RNA-binding protein 39 between cysteines 425 and 478. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3s6e
Structure name
crystal structure of a rna binding motif protein 39 (rbm39) from mus musculus at 0
Structure deposition date
2011-05-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
61
Peptide accession
Q8VH51
Residue number A
425
Residue number B
478
Peptide name
RNA-binding protein 39

Ligandability

Cysteine 425 of RNA-binding protein 39

Cysteine 478 of RNA-binding protein 39

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