a tool for identifying drug-targetable redox-active disulphides

Enhancer of filamentation 1

Intramolecular

Cysteine 509 and cysteine 525 L

A redox-regulated disulphide may form within Enhancer of filamentation 1 between cysteines 509 and 525 (122 and 138 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

59

PDB code

Structure name

solution nmr structure of the serine-rich domain of hef1 (enhancer of filamentation 1) from homo sapiens, northeast structural genomics consortium target hr5554a

Structure deposition date

2010-12-31

Thiol separation (Å)

8

Half-sphere exposure sum ?

28

Minimum pK_a ?

9

% buried

2

Peptide accession

Residue number A

509

Residue number B

525

Peptide name

Enhancer of filamentation 1

Ligandability

Cysteine 509 of Enhancer of filamentation 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 525 of Enhancer of filamentation 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: