ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium channel protein type 5 subunit alpha

Intramolecular
Cysteine 335 and cysteine 341
Cysteine 906 and cysteine 915
Cysteine 1728 and cysteine 1742
Cysteine 1363 and cysteine 1384
Cysteine 280 and cysteine 326
Cysteine 326 and cysteine 335
Cysteine 699 and cysteine 700
Cysteine 280 and cysteine 335
Cysteine 326 and cysteine 341
Cysteine 280 and cysteine 341
A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 335 and 341.

Details

Redox score ?
87
PDB code
7dtc
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2021-01-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
335
Residue number B
341
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 335 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 906 and 915.

Details

Redox score ?
86
PDB code
6lqa
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2020-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
906
Residue number B
915
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 906 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 915 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 1728 and 1742.

Details

Redox score ?
85
PDB code
6lqa
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2020-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
1728
Residue number B
1742
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 1728 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1742 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 1363 and 1384.

Details

Redox score ?
85
PDB code
7dtc
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2021-01-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
1363
Residue number B
1384
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 1363 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1384 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 280 and 326.

Details

Redox score ?
80
PDB code
6lqa
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2020-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
280
Residue number B
326
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 280 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 326 and 335.

Details

Redox score ?
74
PDB code
6lqa
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2020-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
326
Residue number B
335
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 326 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 699 and 700.

Details

Redox score ?
73
PDB code
7dtc
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2021-01-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q14524
Residue number A
699
Residue number B
700
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 699 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 700 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 280 and 335.

Details

Redox score ?
70
PDB code
6lqa
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2020-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
280
Residue number B
335
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 280 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 326 and 341.

Details

Redox score ?
69
PDB code
6lqa
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2020-01-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
326
Residue number B
341
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 326 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 5 subunit alpha between cysteines 280 and 341.

Details

Redox score ?
62
PDB code
7dtc
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2021-01-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14524
Residue number A
280
Residue number B
341
Peptide name
Sodium channel protein type 5 subunit alpha

Ligandability

Cysteine 280 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of Sodium channel protein type 5 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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