ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Squalene monooxygenase

Intermolecular
Cysteine 558 and cysteine 558
A redox-regulated disulphide may form between two units of Squalene monooxygenase at cysteines 558 and 558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6c6r
Structure name
human squalene epoxidase (sqle, squalene monooxygenase) structure with fad
Structure deposition date
2018-01-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
13
% buried
100
Peptide A name
Squalene monooxygenase
Peptide B name
Squalene monooxygenase
Peptide A accession
Q14534
Peptide B accession
Q14534
Peptide A residue number
558
Peptide B residue number
558

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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