ATP-dependent RNA helicase DHX8
Intermolecular
Cysteine 651 and cysteine 651
Cysteine 637 and cysteine 651
Intramolecular
Cysteine 1001 and cysteine 1096
Cysteine 636 and cysteine 637
Cysteine 636 and cysteine 651
6hys C 651 D 651
A redox-regulated disulphide may form between two units of ATP-dependent RNA helicase DHX8 at cysteines 651 and 651.
Details
Redox score ?
64
PDB code
6hys
Structure name
crystal structure of dhx8 helicase domain bound to adp at 2
Structure deposition date
2018-10-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
ATP-dependent RNA helicase DHX8
Peptide B name
ATP-dependent RNA helicase DHX8
Peptide A accession
Q14562
Peptide B accession
Q14562
Peptide A residue number
651
Peptide B residue number
651
Ligandability
6hys C 637 D 651
A redox-regulated disulphide may form between two units of ATP-dependent RNA helicase DHX8 at cysteines 637 and 651. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6hys
Structure name
crystal structure of dhx8 helicase domain bound to adp at 2
Structure deposition date
2018-10-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
ATP-dependent RNA helicase DHX8
Peptide B name
ATP-dependent RNA helicase DHX8
Peptide A accession
Q14562
Peptide B accession
Q14562
Peptide A residue number
637
Peptide B residue number
651
Ligandability
Cysteine 637 of ATP-dependent RNA helicase DHX8
Cysteine 651 of ATP-dependent RNA helicase DHX8
6hyt C 1001 C 1096
A redox-regulated disulphide may form within ATP-dependent RNA helicase DHX8 between cysteines 1001 and 1096.
Details
Redox score ?
65
PDB code
6hyt
Structure name
crystal structure of dhx8 helicase domain bound to adp at 2
Structure deposition date
2018-10-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14562
Residue number A
1001
Residue number B
1096
Peptide name
ATP-dependent RNA helicase DHX8
Ligandability
Cysteine 1001 of ATP-dependent RNA helicase DHX8
Cysteine 1096 of ATP-dependent RNA helicase DHX8
6hyt A 636 A 637
A redox-regulated disulphide may form within ATP-dependent RNA helicase DHX8 between cysteines 636 and 637. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6hyt
Structure name
crystal structure of dhx8 helicase domain bound to adp at 2
Structure deposition date
2018-10-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14562
Residue number A
636
Residue number B
637
Peptide name
ATP-dependent RNA helicase DHX8
Ligandability
Cysteine 636 of ATP-dependent RNA helicase DHX8
Cysteine 637 of ATP-dependent RNA helicase DHX8
6hyt B 636 B 651
A redox-regulated disulphide may form within ATP-dependent RNA helicase DHX8 between cysteines 636 and 651. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6hyt
Structure name
crystal structure of dhx8 helicase domain bound to adp at 2
Structure deposition date
2018-10-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14562
Residue number A
636
Residue number B
651
Peptide name
ATP-dependent RNA helicase DHX8
Ligandability
Cysteine 636 of ATP-dependent RNA helicase DHX8
Cysteine 651 of ATP-dependent RNA helicase DHX8
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