ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Interleukin-11 receptor subunit alpha

Intramolecular
Cysteine 120 and cysteine 130
Cysteine 170 and cysteine 180
Cysteine 26 and cysteine 47
Cysteine 48 and cysteine 94
Cysteine 130 and cysteine 180
Cysteine 130 and cysteine 170
Cysteine 26 and cysteine 48
Cysteine 26 and cysteine 94
Cysteine 120 and cysteine 170
Cysteine 120 and cysteine 180
More...
Cysteine 47 and cysteine 48
Cysteine 47 and cysteine 94
A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 120 and 130 (98 and 108 respectively in this structure).

Details

Redox score ?
84
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
120
Residue number B
130
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 120 of Interleukin-11 receptor subunit alpha

Cysteine 130 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 170 and 180 (148 and 158 respectively in this structure).

Details

Redox score ?
84
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
170
Residue number B
180
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 170 of Interleukin-11 receptor subunit alpha

Cysteine 180 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 26 and 47 (4 and 25 respectively in this structure).

Details

Redox score ?
83
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
26
Residue number B
47
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 26 of Interleukin-11 receptor subunit alpha

Cysteine 47 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 48 and 94 (26 and 72 respectively in this structure).

Details

Redox score ?
82
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
48
Residue number B
94
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 48 of Interleukin-11 receptor subunit alpha

Cysteine 94 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 130 and 180 (108 and 158 respectively in this structure).

Details

Redox score ?
66
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
130
Residue number B
180
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 130 of Interleukin-11 receptor subunit alpha

Cysteine 180 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 130 and 170 (108 and 148 respectively in this structure).

Details

Redox score ?
62
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
130
Residue number B
170
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 130 of Interleukin-11 receptor subunit alpha

Cysteine 170 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 26 and 48 (4 and 26 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
26
Residue number B
48
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 26 of Interleukin-11 receptor subunit alpha

Cysteine 48 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 26 and 94 (4 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
26
Residue number B
94
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 26 of Interleukin-11 receptor subunit alpha

Cysteine 94 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 120 and 170 (98 and 148 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
120
Residue number B
170
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 120 of Interleukin-11 receptor subunit alpha

Cysteine 170 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 120 and 180 (98 and 158 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
120
Residue number B
180
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 120 of Interleukin-11 receptor subunit alpha

Cysteine 180 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 47 and 48 (25 and 26 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
47
Residue number B
48
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 47 of Interleukin-11 receptor subunit alpha

Cysteine 48 of Interleukin-11 receptor subunit alpha

A redox-regulated disulphide may form within Interleukin-11 receptor subunit alpha between cysteines 47 and 94 (25 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6o4p
Structure name
the crystal structure of the interleukin 11 alpha receptor
Structure deposition date
2019-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14626
Residue number A
47
Residue number B
94
Peptide name
Interleukin-11 receptor subunit alpha

Ligandability

Cysteine 47 of Interleukin-11 receptor subunit alpha

Cysteine 94 of Interleukin-11 receptor subunit alpha

If this tool was useful for finding a disulphide, please cite: