a tool for identifying drug-targetable redox-active disulphides

ATP-sensitive inward rectifier potassium channel 11

Intramolecular

Cysteine 110 and cysteine 142

A redox-regulated disulphide may form within ATP-sensitive inward rectifier potassium channel 11 between cysteines 110 and 142.

Details

Redox score ?

84

PDB code

Structure name

cryo-em structure of human katp bound to atp and adp in quatrefoil form

Structure deposition date

2018-01-10

Thiol separation (Å)

2

Half-sphere exposure sum ?

61

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

110

Residue number B

142

Peptide name

ATP-sensitive inward rectifier potassium channel 11

Ligandability

Cysteine 110 of ATP-sensitive inward rectifier potassium channel 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of ATP-sensitive inward rectifier potassium channel 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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