ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pumilio homolog 1

Intramolecular
Cysteine 977 and cysteine 980
Cysteine 964 and cysteine 977
A redox-regulated disulphide may form within Pumilio homolog 1 between cysteines 977 and 980. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3bsx
Structure name
crystal structure of human pumilio 1 in complex with puf5 rna
Structure deposition date
2007-12-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
69
Peptide accession
Q14671
Residue number A
977
Residue number B
980
Peptide name
Pumilio homolog 1

Ligandability

Cysteine 977 of Pumilio homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 980 of Pumilio homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pumilio homolog 1 between cysteines 964 and 977. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3bsb
Structure name
crystal structure of human pumilio1 in complex with cyclinb reverse rna
Structure deposition date
2007-12-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
82
Peptide accession
Q14671
Residue number A
964
Residue number B
977
Peptide name
Pumilio homolog 1

Ligandability

Cysteine 964 of Pumilio homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 977 of Pumilio homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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