Mediator of DNA damage checkpoint protein 1
Intramolecular
Cysteine 1939 and cysteine 2020
Cysteine 2020 and cysteine 2021
Cysteine 2042 and cysteine 2049
Cysteine 62 and cysteine 92
Cysteine 1939 and cysteine 2021
2ado A 1939 A 2020
A redox-regulated disulphide may form within Mediator of DNA damage checkpoint protein 1 between cysteines 1939 and 2020.
Details
Redox score ?
69
PDB code
2ado
Structure name
crystal structure of the brct repeat region from the mediator of dna damage checkpoint protein 1, mdc1
Structure deposition date
2005-07-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
89
Minimum pKa ?
8
% buried
100
Peptide accession
Q14676
Residue number A
1939
Residue number B
2020
Peptide name
Mediator of DNA damage checkpoint protein 1
Ligandability
Cysteine 1939 of Mediator of DNA damage checkpoint protein 1
Cysteine 2020 of Mediator of DNA damage checkpoint protein 1
2azm B 2020 B 2021
A redox-regulated disulphide may form within Mediator of DNA damage checkpoint protein 1 between cysteines 2020 and 2021. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
2azm
Structure name
crystal structure of the mdc1 brct repeat in complex with the histone tail of gamma-h2ax
Structure deposition date
2005-09-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
7
% buried
81
Peptide accession
Q14676
Residue number A
2020
Residue number B
2021
Peptide name
Mediator of DNA damage checkpoint protein 1
Ligandability
Cysteine 2020 of Mediator of DNA damage checkpoint protein 1
Cysteine 2021 of Mediator of DNA damage checkpoint protein 1
2azm A 2042 A 2049
A redox-regulated disulphide may form within Mediator of DNA damage checkpoint protein 1 between cysteines 2042 and 2049. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
2azm
Structure name
crystal structure of the mdc1 brct repeat in complex with the histone tail of gamma-h2ax
Structure deposition date
2005-09-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
23
Peptide accession
Q14676
Residue number A
2042
Residue number B
2049
Peptide name
Mediator of DNA damage checkpoint protein 1
Ligandability
Cysteine 2042 of Mediator of DNA damage checkpoint protein 1
Cysteine 2049 of Mediator of DNA damage checkpoint protein 1
3unn A 62 A 92
A redox-regulated disulphide may form within Mediator of DNA damage checkpoint protein 1 between cysteines 62 and 92. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3unn
Structure name
monomeric structure of the human mdc1 fha domain in complex with an mdc1 phospho-t4 peptide
Structure deposition date
2011-11-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
33
Peptide accession
Q14676
Residue number A
62
Residue number B
92
Peptide name
Mediator of DNA damage checkpoint protein 1
Ligandability
Cysteine 62 of Mediator of DNA damage checkpoint protein 1
Cysteine 92 of Mediator of DNA damage checkpoint protein 1
2ado A 1939 A 2021
A redox-regulated disulphide may form within Mediator of DNA damage checkpoint protein 1 between cysteines 1939 and 2021. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
2ado
Structure name
crystal structure of the brct repeat region from the mediator of dna damage checkpoint protein 1, mdc1
Structure deposition date
2005-07-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
Q14676
Residue number A
1939
Residue number B
2021
Peptide name
Mediator of DNA damage checkpoint protein 1
Ligandability
Cysteine 1939 of Mediator of DNA damage checkpoint protein 1
Cysteine 2021 of Mediator of DNA damage checkpoint protein 1
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