ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

DNA replication complex GINS protein PSF1

Intramolecular
Cysteine 3 and cysteine 75
Cysteine 3 and cysteine 67
A redox-regulated disulphide may form within DNA replication complex GINS protein PSF1 between cysteines 3 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
2eho
Structure name
crystal structure of human gins complex
Structure deposition date
2007-03-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
99
Peptide accession
Q14691
Residue number A
3
Residue number B
75
Peptide name
DNA replication complex GINS protein PSF1

Ligandability

Cysteine 3 of DNA replication complex GINS protein PSF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of DNA replication complex GINS protein PSF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA replication complex GINS protein PSF1 between cysteines 3 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2q9q
Structure name
the crystal structure of full length human gins complex
Structure deposition date
2007-06-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
88
Peptide accession
Q14691
Residue number A
3
Residue number B
67
Peptide name
DNA replication complex GINS protein PSF1

Ligandability

Cysteine 3 of DNA replication complex GINS protein PSF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of DNA replication complex GINS protein PSF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: