ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neutral alpha-glucosidase AB

Intramolecular
Cysteine 41 and cysteine 47
Cysteine 633 and cysteine 644
A redox-regulated disulphide may form within Neutral alpha-glucosidase AB between cysteines 41 and 47.

Details

Redox score ?
86
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14697
Residue number A
41
Residue number B
47
Peptide name
Neutral alpha-glucosidase AB

Ligandability

Cysteine 41 of Neutral alpha-glucosidase AB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Neutral alpha-glucosidase AB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neutral alpha-glucosidase AB between cysteines 633 and 644.

Details

Redox score ?
78
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14697
Residue number A
633
Residue number B
644
Peptide name
Neutral alpha-glucosidase AB

Ligandability

Cysteine 633 of Neutral alpha-glucosidase AB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 644 of Neutral alpha-glucosidase AB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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