Isoform 3 of Metabotropic glutamate receptor 7
Intermolecular
Cysteine 136 and cysteine 136
Intramolecular
Cysteine 374 and cysteine 390
Cysteine 563 and cysteine 576
Cysteine 548 and cysteine 560
Cysteine 527 and cysteine 545
Cysteine 655 and cysteine 749
Cysteine 430 and cysteine 437
Cysteine 523 and cysteine 542
Cysteine 67 and cysteine 109
Cysteine 249 and cysteine 541
More...Cysteine 541 and cysteine 542
Cysteine 249 and cysteine 523
Cysteine 523 and cysteine 541
Cysteine 249 and cysteine 542
Cysteine 770 and cysteine 798
Cysteine 545 and cysteine 560
Cysteine 545 and cysteine 548
7epc A 136 B 136
A redox-regulated disulphide may form between two units of Isoform 3 of Metabotropic glutamate receptor 7 at cysteines 136 and 136.
Details
Redox score ?
94
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Isoform 3 of Metabotropic glutamate receptor 7
Peptide B name
Isoform 3 of Metabotropic glutamate receptor 7
Peptide A accession
Q14831-3
Peptide B accession
Q14831-3
Peptide A residue number
136
Peptide B residue number
136
Ligandability
3mq4 A 374 A 390
A redox-regulated disulphide may form within Metabotropic glutamate receptor 7 between cysteines 374 and 390.
Details
Redox score ?
90
PDB code
3mq4
Structure name
metabotropic glutamate receptor mglur7 complexed with ly341495 antagonist
Structure deposition date
2010-04-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831
Residue number A
374
Residue number B
390
Peptide name
Metabotropic glutamate receptor 7
Ligandability
Cysteine 374 of Metabotropic glutamate receptor 7
Cysteine 390 of Metabotropic glutamate receptor 7
7epc B 563 B 576
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 563 and 576.
Details
Redox score ?
89
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
563
Residue number B
576
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 563 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 576 of Isoform 3 of Metabotropic glutamate receptor 7
7epc B 548 B 560
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 548 and 560.
Details
Redox score ?
88
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
548
Residue number B
560
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 548 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 560 of Isoform 3 of Metabotropic glutamate receptor 7
7epc B 527 B 545
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 527 and 545.
Details
Redox score ?
88
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
527
Residue number B
545
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 527 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 545 of Isoform 3 of Metabotropic glutamate receptor 7
7epc B 655 B 749
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 655 and 749.
Details
Redox score ?
87
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
655
Residue number B
749
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 655 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 749 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 430 A 437
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 430 and 437.
Details
Redox score ?
87
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
430
Residue number B
437
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 430 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 437 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 523 A 542
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 523 and 542.
Details
Redox score ?
86
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
523
Residue number B
542
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 523 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 542 of Isoform 3 of Metabotropic glutamate receptor 7
2e4z A 67 A 109
A redox-regulated disulphide may form within Metabotropic glutamate receptor 7 between cysteines 67 and 109.
Details
Redox score ?
83
PDB code
2e4z
Structure name
crystal structure of the ligand-binding region of the group iii metabotropic glutamate receptor
Structure deposition date
2006-12-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35400
Residue number A
67
Residue number B
109
Peptide name
Metabotropic glutamate receptor 7
Ligandability
Cysteine 67 of Metabotropic glutamate receptor 7
Cysteine 109 of Metabotropic glutamate receptor 7
7epc A 249 A 541
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 249 and 541.
Details
Redox score ?
81
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
249
Residue number B
541
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 249 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 541 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 541 A 542
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 541 and 542.
Details
Redox score ?
67
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
541
Residue number B
542
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 541 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 542 of Isoform 3 of Metabotropic glutamate receptor 7
7epc B 249 B 523
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 249 and 523.
Details
Redox score ?
63
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
249
Residue number B
523
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 249 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 523 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 523 A 541
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 523 and 541.
Details
Redox score ?
63
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
523
Residue number B
541
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 523 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 541 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 249 A 542
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 249 and 542. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
249
Residue number B
542
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 249 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 542 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 770 A 798
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 770 and 798. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
21
Peptide accession
Q14831-3
Residue number A
770
Residue number B
798
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 770 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 798 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 545 A 560
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 545 and 560. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
545
Residue number B
560
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 545 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 560 of Isoform 3 of Metabotropic glutamate receptor 7
7epc A 545 A 548
A redox-regulated disulphide may form within Isoform 3 of Metabotropic glutamate receptor 7 between cysteines 545 and 548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7epc
Structure name
cryo-em structure of inactive mglu7 homodimer
Structure deposition date
2021-04-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14831-3
Residue number A
545
Residue number B
548
Peptide name
Isoform 3 of Metabotropic glutamate receptor 7
Ligandability
Cysteine 545 of Isoform 3 of Metabotropic glutamate receptor 7
Cysteine 548 of Isoform 3 of Metabotropic glutamate receptor 7
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