Metabotropic glutamate receptor 3
Intramolecular
Cysteine 549 and cysteine 562
Cysteine 534 and cysteine 546
Cysteine 412 and cysteine 419
Cysteine 361 and cysteine 373
Cysteine 513 and cysteine 531
Cysteine 57 and cysteine 99
Cysteine 509 and cysteine 528
Cysteine 240 and cysteine 527
Cysteine 641 and cysteine 730
Cysteine 527 and cysteine 528
More...Cysteine 509 and cysteine 527
Cysteine 240 and cysteine 528
Cysteine 240 and cysteine 509
Cysteine 513 and cysteine 534
Cysteine 546 and cysteine 549
Cysteine 534 and cysteine 549
Cysteine 513 and cysteine 546
Cysteine 665 and cysteine 692
Cysteine 531 and cysteine 534
Cysteine 546 and cysteine 562
7wi8 A 549 A 562
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 549 and 562.
Details
Redox score ?
89
PDB code
7wi8
Structure name
cryo-em structure of inactive mglu3 bound to ly341495
Structure deposition date
2022-01-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14832
Residue number A
549
Residue number B
562
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 549 of Metabotropic glutamate receptor 3
Cysteine 562 of Metabotropic glutamate receptor 3
7wi6 B 534 B 546
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 534 and 546.
Details
Redox score ?
88
PDB code
7wi6
Structure name
cryo-em structure of ly341495/nam-bound mglu3
Structure deposition date
2022-01-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14832
Residue number A
534
Residue number B
546
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 534 of Metabotropic glutamate receptor 3
Cysteine 546 of Metabotropic glutamate receptor 3
5cnk C 412 C 419
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 412 and 419.
Details
Redox score ?
88
PDB code
5cnk
Structure name
mglur3 with glutamate
Structure deposition date
2015-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14832
Residue number A
412
Residue number B
419
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 412 of Metabotropic glutamate receptor 3
Cysteine 419 of Metabotropic glutamate receptor 3
2e4v A 361 A 373
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 361 and 373.
Details
Redox score ?
87
PDB code
2e4v
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with dcg-iv
Structure deposition date
2006-12-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
361
Residue number B
373
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 361 of Metabotropic glutamate receptor 3
Cysteine 373 of Metabotropic glutamate receptor 3
7wi8 A 513 A 531
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 513 and 531.
Details
Redox score ?
86
PDB code
7wi8
Structure name
cryo-em structure of inactive mglu3 bound to ly341495
Structure deposition date
2022-01-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14832
Residue number A
513
Residue number B
531
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 513 of Metabotropic glutamate receptor 3
Cysteine 531 of Metabotropic glutamate receptor 3
2e4w A 57 A 99
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 57 and 99.
Details
Redox score ?
83
PDB code
2e4w
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with 1s,3s-acpd
Structure deposition date
2006-12-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
57
Residue number B
99
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 57 of Metabotropic glutamate receptor 3
Cysteine 99 of Metabotropic glutamate receptor 3
7wi8 A 509 A 528
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 509 and 528.
Details
Redox score ?
83
PDB code
7wi8
Structure name
cryo-em structure of inactive mglu3 bound to ly341495
Structure deposition date
2022-01-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14832
Residue number A
509
Residue number B
528
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 509 of Metabotropic glutamate receptor 3
Cysteine 528 of Metabotropic glutamate receptor 3
7wi6 B 240 B 527
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 240 and 527.
Details
Redox score ?
81
PDB code
7wi6
Structure name
cryo-em structure of ly341495/nam-bound mglu3
Structure deposition date
2022-01-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14832
Residue number A
240
Residue number B
527
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 240 of Metabotropic glutamate receptor 3
Cysteine 527 of Metabotropic glutamate receptor 3
7wi6 B 641 B 730
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 641 and 730.
Details
Redox score ?
80
PDB code
7wi6
Structure name
cryo-em structure of ly341495/nam-bound mglu3
Structure deposition date
2022-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
17
Peptide accession
Q14832
Residue number A
641
Residue number B
730
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 641 of Metabotropic glutamate receptor 3
Cysteine 730 of Metabotropic glutamate receptor 3
2e4w A 527 A 528
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 527 and 528.
Details
Redox score ?
61
PDB code
2e4w
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with 1s,3s-acpd
Structure deposition date
2006-12-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
527
Residue number B
528
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 527 of Metabotropic glutamate receptor 3
Cysteine 528 of Metabotropic glutamate receptor 3
2e4v B 509 B 527
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 509 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
2e4v
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with dcg-iv
Structure deposition date
2006-12-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
509
Residue number B
527
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 509 of Metabotropic glutamate receptor 3
Cysteine 527 of Metabotropic glutamate receptor 3
2e4w B 240 B 528
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 240 and 528. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2e4w
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with 1s,3s-acpd
Structure deposition date
2006-12-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
240
Residue number B
528
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 240 of Metabotropic glutamate receptor 3
Cysteine 528 of Metabotropic glutamate receptor 3
7wi6 A 240 A 509
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 240 and 509. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7wi6
Structure name
cryo-em structure of ly341495/nam-bound mglu3
Structure deposition date
2022-01-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14832
Residue number A
240
Residue number B
509
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 240 of Metabotropic glutamate receptor 3
Cysteine 509 of Metabotropic glutamate receptor 3
2e4y A 513 A 534
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 513 and 534. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
2e4y
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with 2r,4r-apdc
Structure deposition date
2006-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
513
Residue number B
534
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 513 of Metabotropic glutamate receptor 3
Cysteine 534 of Metabotropic glutamate receptor 3
2e4v B 546 B 549
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 546 and 549. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
2e4v
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with dcg-iv
Structure deposition date
2006-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
546
Residue number B
549
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 546 of Metabotropic glutamate receptor 3
Cysteine 549 of Metabotropic glutamate receptor 3
2e4u A 534 A 549
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 534 and 549. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
2e4u
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with l-glutamate
Structure deposition date
2006-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
534
Residue number B
549
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 534 of Metabotropic glutamate receptor 3
Cysteine 549 of Metabotropic glutamate receptor 3
2e4x A 513 A 546
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 513 and 546. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
2e4x
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with 1s,3r-acpd
Structure deposition date
2006-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
513
Residue number B
546
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 513 of Metabotropic glutamate receptor 3
Cysteine 546 of Metabotropic glutamate receptor 3
7wi8 B 665 B 692
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 665 and 692. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7wi8
Structure name
cryo-em structure of inactive mglu3 bound to ly341495
Structure deposition date
2022-01-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide accession
Q14832
Residue number A
665
Residue number B
692
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 665 of Metabotropic glutamate receptor 3
Cysteine 692 of Metabotropic glutamate receptor 3
2e4y A 531 A 534
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 531 and 534. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2e4y
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with 2r,4r-apdc
Structure deposition date
2006-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
531
Residue number B
534
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 531 of Metabotropic glutamate receptor 3
Cysteine 534 of Metabotropic glutamate receptor 3
2e4v B 546 B 562
A redox-regulated disulphide may form within Metabotropic glutamate receptor 3 between cysteines 546 and 562. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
2e4v
Structure name
crystal structure of the extracellular region of the group ii metabotropic glutamate receptor complexed with dcg-iv
Structure deposition date
2006-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31422
Residue number A
546
Residue number B
562
Peptide name
Metabotropic glutamate receptor 3
Ligandability
Cysteine 546 of Metabotropic glutamate receptor 3
Cysteine 562 of Metabotropic glutamate receptor 3
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