Metabotropic glutamate receptor 4
Intramolecular
Cysteine 524 and cysteine 542
Cysteine 560 and cysteine 573
Cysteine 545 and cysteine 557
Cysteine 428 and cysteine 435
Cysteine 520 and cysteine 539
Cysteine 652 and cysteine 746
Cysteine 249 and cysteine 538
Cysteine 372 and cysteine 388
Cysteine 538 and cysteine 539
Cysteine 249 and cysteine 539
More...Cysteine 249 and cysteine 520
Cysteine 520 and cysteine 538
Cysteine 67 and cysteine 109
Cysteine 539 and cysteine 542
Cysteine 767 and cysteine 795
7e9h R 524 R 542
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 524 and 542.
Details
Redox score ?
89
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
524
Residue number B
542
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 524 of Metabotropic glutamate receptor 4
Cysteine 542 of Metabotropic glutamate receptor 4
7e9h S 560 S 573
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 560 and 573.
Details
Redox score ?
88
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
560
Residue number B
573
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 560 of Metabotropic glutamate receptor 4
Cysteine 573 of Metabotropic glutamate receptor 4
7e9h S 545 S 557
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 545 and 557.
Details
Redox score ?
88
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
545
Residue number B
557
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 545 of Metabotropic glutamate receptor 4
Cysteine 557 of Metabotropic glutamate receptor 4
7e9h R 428 R 435
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 428 and 435.
Details
Redox score ?
87
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
428
Residue number B
435
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 428 of Metabotropic glutamate receptor 4
Cysteine 435 of Metabotropic glutamate receptor 4
7e9h S 520 S 539
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 520 and 539.
Details
Redox score ?
86
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
520
Residue number B
539
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 520 of Metabotropic glutamate receptor 4
Cysteine 539 of Metabotropic glutamate receptor 4
7e9h S 652 S 746
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 652 and 746.
Details
Redox score ?
85
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
652
Residue number B
746
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 652 of Metabotropic glutamate receptor 4
Cysteine 746 of Metabotropic glutamate receptor 4
7e9h R 249 R 538
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 249 and 538.
Details
Redox score ?
82
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
249
Residue number B
538
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 249 of Metabotropic glutamate receptor 4
Cysteine 538 of Metabotropic glutamate receptor 4
7e9h R 372 R 388
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 372 and 388.
Details
Redox score ?
82
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
9
% buried
0
Peptide accession
Q14833
Residue number A
372
Residue number B
388
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 372 of Metabotropic glutamate receptor 4
Cysteine 388 of Metabotropic glutamate receptor 4
7e9h S 538 S 539
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 538 and 539.
Details
Redox score ?
70
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
538
Residue number B
539
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 538 of Metabotropic glutamate receptor 4
Cysteine 539 of Metabotropic glutamate receptor 4
7e9h R 249 R 539
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 249 and 539.
Details
Redox score ?
61
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
249
Residue number B
539
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 249 of Metabotropic glutamate receptor 4
Cysteine 539 of Metabotropic glutamate receptor 4
7e9h R 249 R 520
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 249 and 520. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
249
Residue number B
520
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 249 of Metabotropic glutamate receptor 4
Cysteine 520 of Metabotropic glutamate receptor 4
7e9h R 520 R 538
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 520 and 538. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
520
Residue number B
538
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 520 of Metabotropic glutamate receptor 4
Cysteine 538 of Metabotropic glutamate receptor 4
7e9h S 67 S 109
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 67 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
23
Peptide accession
Q14833
Residue number A
67
Residue number B
109
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 67 of Metabotropic glutamate receptor 4
Cysteine 109 of Metabotropic glutamate receptor 4
7e9h S 539 S 542
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 539 and 542. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14833
Residue number A
539
Residue number B
542
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 539 of Metabotropic glutamate receptor 4
Cysteine 542 of Metabotropic glutamate receptor 4
7e9h S 767 S 795
A redox-regulated disulphide may form within Metabotropic glutamate receptor 4 between cysteines 767 and 795. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7e9h
Structure name
cryo-em structure of gi-bound metabotropic glutamate receptor mglu4
Structure deposition date
2021-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
37
Peptide accession
Q14833
Residue number A
767
Residue number B
795
Peptide name
Metabotropic glutamate receptor 4
Ligandability
Cysteine 767 of Metabotropic glutamate receptor 4
Cysteine 795 of Metabotropic glutamate receptor 4
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