ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ketimine reductase mu-crystallin

Intermolecular
Cysteine 283 and cysteine 283
Intramolecular
Cysteine 140 and cysteine 188
A redox-regulated disulphide may form between two units of Ketimine reductase mu-crystallin at cysteines 283 and 283.

Details

Redox score ?
75
PDB code
4bv8
Structure name
crystal structure of the apo form of mouse mu-crystallin
Structure deposition date
2013-06-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
86
Minimum pKa ?
8
% buried
92
Peptide A name
Ketimine reductase mu-crystallin
Peptide B name
Ketimine reductase mu-crystallin
Peptide A accession
O54983
Peptide B accession
O54983
Peptide A residue number
283
Peptide B residue number
283

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ketimine reductase mu-crystallin between cysteines 140 and 188. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2i99
Structure name
crystal structure of human mu_crystallin at 2
Structure deposition date
2006-09-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
70
Peptide accession
Q14894
Residue number A
140
Residue number B
188
Peptide name
Ketimine reductase mu-crystallin

Ligandability

Cysteine 140 of Ketimine reductase mu-crystallin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Ketimine reductase mu-crystallin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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