ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Opioid-binding protein/cell adhesion molecule

Intramolecular
Cysteine 157 and cysteine 202
Cysteine 244 and cysteine 296
Cysteine 57 and cysteine 115
A redox-regulated disulphide may form within Opioid-binding protein/cell adhesion molecule between cysteines 157 and 202.

Details

Redox score ?
83
PDB code
5uv6
Structure name
crystal structure of human opioid binding protein/cell adhesion molecule like (opcml)
Structure deposition date
2017-02-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14982
Residue number A
157
Residue number B
202
Peptide name
Opioid-binding protein/cell adhesion molecule

Ligandability

Cysteine 157 of Opioid-binding protein/cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Opioid-binding protein/cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Opioid-binding protein/cell adhesion molecule between cysteines 244 and 296.

Details

Redox score ?
81
PDB code
5uv6
Structure name
crystal structure of human opioid binding protein/cell adhesion molecule like (opcml)
Structure deposition date
2017-02-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14982
Residue number A
244
Residue number B
296
Peptide name
Opioid-binding protein/cell adhesion molecule

Ligandability

Cysteine 244 of Opioid-binding protein/cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Opioid-binding protein/cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Opioid-binding protein/cell adhesion molecule between cysteines 57 and 115.

Details

Redox score ?
80
PDB code
5uv6
Structure name
crystal structure of human opioid binding protein/cell adhesion molecule like (opcml)
Structure deposition date
2017-02-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14982
Residue number A
57
Residue number B
115
Peptide name
Opioid-binding protein/cell adhesion molecule

Ligandability

Cysteine 57 of Opioid-binding protein/cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Opioid-binding protein/cell adhesion molecule

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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