ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ataxin-7-like protein 3

Intramolecular
Cysteine 220 and cysteine 226
Cysteine 209 and cysteine 220
Cysteine 209 and cysteine 226
A redox-regulated disulphide may form within Ataxin-7-like protein 3 between cysteines 220 and 226.

Details

Redox score ?
85
PDB code
2kkt
Structure name
solution structure of the sca7 domain of human ataxin-7-l3 protein
Structure deposition date
2009-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
1
Peptide accession
Q14CW9
Residue number A
220
Residue number B
226
Peptide name
Ataxin-7-like protein 3

Ligandability

Cysteine 220 of Ataxin-7-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Ataxin-7-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ataxin-7-like protein 3 between cysteines 209 and 220.

Details

Redox score ?
82
PDB code
2kkt
Structure name
solution structure of the sca7 domain of human ataxin-7-l3 protein
Structure deposition date
2009-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
6
Peptide accession
Q14CW9
Residue number A
209
Residue number B
220
Peptide name
Ataxin-7-like protein 3

Ligandability

Cysteine 209 of Ataxin-7-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Ataxin-7-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ataxin-7-like protein 3 between cysteines 209 and 226.

Details

Redox score ?
77
PDB code
2kkt
Structure name
solution structure of the sca7 domain of human ataxin-7-l3 protein
Structure deposition date
2009-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
4
Peptide accession
Q14CW9
Residue number A
209
Residue number B
226
Peptide name
Ataxin-7-like protein 3

Ligandability

Cysteine 209 of Ataxin-7-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Ataxin-7-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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