ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N-alpha-acetyltransferase 25, NatB auxiliary subunit

Intramolecular
Cysteine 365 and cysteine 416 L
Cysteine 769 and cysteine 772
Cysteine 364 and cysteine 365
Cysteine 769 and cysteine 819
Cysteine 364 and cysteine 416 L
A redox-regulated disulphide may form within N-alpha-acetyltransferase 25, NatB auxiliary subunit between cysteines 365 and 416.

Details

Redox score ?
68
PDB code
7stx
Structure name
cryo-em structure of human natb in complex with coa-alpha-synuclein
Structure deposition date
2021-11-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
100
Peptide accession
Q14CX7
Residue number A
365
Residue number B
416
Peptide name
N-alpha-acetyltransferase 25, NatB auxiliary subunit

Ligandability

Cysteine 365 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 25, NatB auxiliary subunit between cysteines 769 and 772. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6vp9
Structure name
cryo-em structure of human natb complex
Structure deposition date
2020-02-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
90
Peptide accession
Q14CX7
Residue number A
769
Residue number B
772
Peptide name
N-alpha-acetyltransferase 25, NatB auxiliary subunit

Ligandability

Cysteine 769 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 772 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 25, NatB auxiliary subunit between cysteines 364 and 365. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7stx
Structure name
cryo-em structure of human natb in complex with coa-alpha-synuclein
Structure deposition date
2021-11-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
100
Peptide accession
Q14CX7
Residue number A
364
Residue number B
365
Peptide name
N-alpha-acetyltransferase 25, NatB auxiliary subunit

Ligandability

Cysteine 364 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 25, NatB auxiliary subunit between cysteines 769 and 819. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7stx
Structure name
cryo-em structure of human natb in complex with coa-alpha-synuclein
Structure deposition date
2021-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
81
Peptide accession
Q14CX7
Residue number A
769
Residue number B
819
Peptide name
N-alpha-acetyltransferase 25, NatB auxiliary subunit

Ligandability

Cysteine 769 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 819 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 25, NatB auxiliary subunit between cysteines 364 and 416. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6vp9
Structure name
cryo-em structure of human natb complex
Structure deposition date
2020-02-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
100
Peptide accession
Q14CX7
Residue number A
364
Residue number B
416
Peptide name
N-alpha-acetyltransferase 25, NatB auxiliary subunit

Ligandability

Cysteine 364 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of N-alpha-acetyltransferase 25, NatB auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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