a tool for identifying drug-targetable redox-active disulphides

Signal peptidase complex subunit 2

Intramolecular

Cysteine 88 and cysteine 92

A redox-regulated disulphide may form within Signal peptidase complex subunit 2 between cysteines 88 and 92.

Details

Redox score ?

64

PDB code

Structure name

human signal peptidase complex paralog a (spc-a)

Structure deposition date

2021-07-06

Thiol separation (Å)

6

Half-sphere exposure sum ?

58

Minimum pK_a ?

9

% buried

21

Peptide accession

Residue number A

88

Residue number B

92

Peptide name

Signal peptidase complex subunit 2

Ligandability

Cysteine 88 of Signal peptidase complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Signal peptidase complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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