Pre-mRNA-splicing regulator WTAP
7vf2 C 90 D 90
A redox-regulated disulphide may form between two units of Pre-mRNA-splicing regulator WTAP at cysteines 90 and 90.
Details
Redox score ?
62
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
30
Peptide A name
Pre-mRNA-splicing regulator WTAP
Peptide B name
Pre-mRNA-splicing regulator WTAP
Peptide A accession
Q15007
Peptide B accession
Q15007
Peptide A residue number
90
Peptide B residue number
90
Ligandability
7yfj A 32 B 32
A redox-regulated disulphide may form between two units of Pre-mRNA-splicing regulator WTAP at cysteines 161 and 161 (32 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7yfj
Structure name
crystal structure of human wtap
Structure deposition date
2022-07-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
0
Peptide A name
Pre-mRNA-splicing regulator WTAP
Peptide B name
Pre-mRNA-splicing regulator WTAP
Peptide A accession
Q15007
Peptide B accession
Q15007
Peptide A residue number
161
Peptide B residue number
161
Ligandability
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