a tool for identifying drug-targetable redox-active disulphides

BRISC complex subunit Abraxas 2

Intermolecular

Cysteine 156 of Lys-63-specific deubiquitinase BRCC36 and cysteine 14

A redox-regulated disulphide may form between cysteine 156 of Lys-63-specific deubiquitinase BRCC36 and cysteine 14 of BRISC complex subunit Abraxas 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

26

PDB code

Structure name

cryo-em structure of the human brisc-shmt2 complex

Structure deposition date

2019-04-01

Thiol separation (Å)

10

Half-sphere exposure sum ?

80

Minimum pK_a ?

13

% buried

100

Peptide A name

Lys-63-specific deubiquitinase BRCC36

Peptide B name

BRISC complex subunit Abraxas 2

Peptide A accession

Peptide B accession

Peptide A residue number

156

Peptide B residue number

14

Ligandability

Cysteine 156 of Lys-63-specific deubiquitinase BRCC36

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 14 of BRISC complex subunit Abraxas 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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