ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Squamous cell carcinoma antigen recognized by T-cells 3

Intramolecular
Cysteine 341 and cysteine 375
Cysteine 812 and cysteine 821
A redox-regulated disulphide may form within Squamous cell carcinoma antigen recognized by T-cells 3 between cysteines 341 and 375. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
5ctq
Structure name
crystal structure of human sart3/tip110 half-a tpr (hat) domain
Structure deposition date
2015-07-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
60
Peptide accession
Q15020
Residue number A
341
Residue number B
375
Peptide name
Squamous cell carcinoma antigen recognized by T-cells 3

Ligandability

Cysteine 341 of Squamous cell carcinoma antigen recognized by T-cells 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Squamous cell carcinoma antigen recognized by T-cells 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Squamous cell carcinoma antigen recognized by T-cells 3 between cysteines 812 and 821. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2do4
Structure name
solution structure of the rna binding domain of squamous cell carcinoma antigen recognized by t cells 3
Structure deposition date
2006-04-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
48
Peptide accession
Q15020
Residue number A
812
Residue number B
821
Peptide name
Squamous cell carcinoma antigen recognized by T-cells 3

Ligandability

Cysteine 812 of Squamous cell carcinoma antigen recognized by T-cells 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 821 of Squamous cell carcinoma antigen recognized by T-cells 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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