Polycomb protein SUZ12

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

201

Residue number B

636

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 201 of Polycomb protein SUZ12

Cysteine 636 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 450 and 457. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of a suz12-rbbp4-jarid2-aebp2 heterotetrameric complex

Structure deposition date

2017-06-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

450

Residue number B

457

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 450 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 457 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 453 and 470. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of a suz12-rbbp4-jarid2-aebp2 heterotetrameric complex

Structure deposition date

2017-06-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

453

Residue number B

470

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 453 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 470 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 453 and 457. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of a suz12-rbbp4-jarid2-aebp2 heterotetrameric complex

Structure deposition date

2017-06-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

453

Residue number B

457

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 453 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 457 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 450 and 470. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of a suz12-rbbp4-jarid2-aebp2 heterotetrameric complex

Structure deposition date

2017-06-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

450

Residue number B

470

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 450 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 470 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 457 and 470. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

crystal structure of a suz12-rbbp4-jarid2-aebp2 heterotetrameric complex

Structure deposition date

2017-06-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Residue number A

457

Residue number B

470

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 457 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 470 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 531 and 453 (560 and 604 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

531

Residue number B

453

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 531 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 453 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Uncertain whether structure cysteine 604 has been assigned to correct residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 636 and 588 (573 and 588 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

636

Residue number B

588

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 636 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 588 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 588 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 457 and 192 (286 and 289 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

457

Residue number B

192

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 457 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 192 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Uncertain whether structure cysteine 289 has been assigned to correct residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 201 and 453 (601 and 604 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

201

Residue number B

453

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 201 of Polycomb protein SUZ12

Cysteine 453 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Uncertain whether structure cysteine 604 has been assigned to correct residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 457 and 294 (286 and 294 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

457

Residue number B

294

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 457 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 294 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 294 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 653 and 553 (543 and 553 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

653

Residue number B

553

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 653 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 553 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 553 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 201 and 585 (566 and 585 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

201

Residue number B

585

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 201 of Polycomb protein SUZ12

Cysteine 585 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 585 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 201 and 553 (534 and 553 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

201

Residue number B

553

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 201 of Polycomb protein SUZ12

Cysteine 553 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 553 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 653 and 547 (543 and 547 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

653

Residue number B

547

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 653 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 547 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 547 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 653 and 549 (543 and 549 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

653

Residue number B

549

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 653 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 549 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 549 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 192 and 453 (580 and 604 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

192

Residue number B

453

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 192 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 453 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Uncertain whether structure cysteine 580 has been assigned to correct residue.

Uncertain whether structure cysteine 604 has been assigned to correct residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 192 and 585 (580 and 585 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

192

Residue number B

585

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 192 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 585 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Uncertain whether structure cysteine 580 has been assigned to correct residue.

Cysteine 585 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 562 and 588.

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

562

Residue number B

588

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 562 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 588 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 562 in protein A could not be asigned to a Uniprot residue.

Cysteine 588 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 547 and 553.

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

547

Residue number B

553

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 547 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 553 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 547 in protein A could not be asigned to a Uniprot residue.

Cysteine 553 in protein B could not be asigned to a Uniprot residue.

A redox-regulated disulphide may form within Polycomb protein SUZ12 between cysteines 523 and 547.

Details

Redox score ?

nan

PDB code

Structure name

human polycomb repressive complex 2 in complex with gsk126 inhibitor

Structure deposition date

2017-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

523

Residue number B

547

Peptide name

Polycomb protein SUZ12

Ligandability

Cysteine 523 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.

Cysteine 547 of Polycomb protein SUZ12

Not ligandable in the dataset of Vinogradova et al.