ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Exosome complex component RRP42

Intramolecular
Cysteine 125 and cysteine 132
Cysteine 204 and cysteine 221
Cysteine 85 and cysteine 144 L
A redox-regulated disulphide may form within Exosome complex component RRP42 between cysteines 125 and 132.

Details

Redox score ?
71
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
9
Peptide accession
Q15024
Residue number A
125
Residue number B
132
Peptide name
Exosome complex component RRP42

Ligandability

Cysteine 125 of Exosome complex component RRP42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Exosome complex component RRP42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP42 between cysteines 204 and 221. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
74
Peptide accession
Q15024
Residue number A
204
Residue number B
221
Peptide name
Exosome complex component RRP42

Ligandability

Cysteine 204 of Exosome complex component RRP42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Exosome complex component RRP42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP42 between cysteines 85 and 144. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
68
Peptide accession
Q15024
Residue number A
85
Residue number B
144
Peptide name
Exosome complex component RRP42

Ligandability

Cysteine 85 of Exosome complex component RRP42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Exosome complex component RRP42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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