116 kDa U5 small nuclear ribonucleoprotein component
Intramolecular
Cysteine 144 and cysteine 148 L
Cysteine 308 and cysteine 317
Cysteine 256 and cysteine 317
Cysteine 256 and cysteine 308
Cysteine 144 and cysteine 166 L
Cysteine 148 and cysteine 166
Cysteine 148 and cysteine 420
Cysteine 308 and cysteine 434
Cysteine 317 and cysteine 434
Cysteine 256 and cysteine 434
More...Cysteine 148 and cysteine 317
Cysteine 663 and cysteine 780
6ff4 B 144 B 148
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 144 and 148.
Details
Redox score ?
68
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
100
Peptide accession
Q15029
Residue number A
144
Residue number B
148
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 144 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 148 of 116 kDa U5 small nuclear ribonucleoprotein component
6id0 C 308 C 317
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 308 and 317.
Details
Redox score ?
66
PDB code
6id0
Structure name
cryo-em structure of a human intron lariat spliceosome prior to prp43 loaded (ils1 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
100
Peptide accession
Q15029
Residue number A
308
Residue number B
317
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 308 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 317 of 116 kDa U5 small nuclear ribonucleoprotein component
6icz C 256 C 317
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 256 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide accession
Q15029
Residue number A
256
Residue number B
317
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 256 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 317 of 116 kDa U5 small nuclear ribonucleoprotein component
7dvq C 256 C 308
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 256 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
15
% buried
100
Peptide accession
Q15029
Residue number A
256
Residue number B
308
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 256 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 308 of 116 kDa U5 small nuclear ribonucleoprotein component
6ff4 B 144 B 166
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 144 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
16
% buried
100
Peptide accession
Q15029
Residue number A
144
Residue number B
166
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 144 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 166 of 116 kDa U5 small nuclear ribonucleoprotein component
6ff4 B 148 B 166
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 148 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
7
% buried
100
Peptide accession
Q15029
Residue number A
148
Residue number B
166
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 148 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 166 of 116 kDa U5 small nuclear ribonucleoprotein component
6ff4 B 148 B 420
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 148 and 420. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
7
% buried
100
Peptide accession
Q15029
Residue number A
148
Residue number B
420
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 148 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 420 of 116 kDa U5 small nuclear ribonucleoprotein component
6ff4 B 308 B 434
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 308 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q15029
Residue number A
308
Residue number B
434
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 308 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 434 of 116 kDa U5 small nuclear ribonucleoprotein component
6id1 C 317 C 434
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 317 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6id1
Structure name
cryo-em structure of a human intron lariat spliceosome after prp43 loaded (ils2 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
100
Peptide accession
Q15029
Residue number A
317
Residue number B
434
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 317 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 434 of 116 kDa U5 small nuclear ribonucleoprotein component
6icz C 256 C 434
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 256 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
10
% buried
100
Peptide accession
Q15029
Residue number A
256
Residue number B
434
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 256 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 434 of 116 kDa U5 small nuclear ribonucleoprotein component
6id0 C 148 C 317
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 148 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6id0
Structure name
cryo-em structure of a human intron lariat spliceosome prior to prp43 loaded (ils1 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
100
Peptide accession
Q15029
Residue number A
148
Residue number B
317
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 148 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 317 of 116 kDa U5 small nuclear ribonucleoprotein component
7w59 C 663 C 780
A redox-regulated disulphide may form within 116 kDa U5 small nuclear ribonucleoprotein component between cysteines 663 and 780. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
7w59
Structure name
the cryo-em structure of human pre-c*-i complex
Structure deposition date
2021-11-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
98
Peptide accession
Q15029
Residue number A
663
Residue number B
780
Peptide name
116 kDa U5 small nuclear ribonucleoprotein component
Ligandability
Cysteine 663 of 116 kDa U5 small nuclear ribonucleoprotein component
Cysteine 780 of 116 kDa U5 small nuclear ribonucleoprotein component
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