a tool for identifying drug-targetable redox-active disulphides

Rho guanine nucleotide exchange factor 6

Intramolecular

Cysteine 57 and cysteine 66

Cysteine 42 and cysteine 57

Cysteine 42 and cysteine 77

Cysteine 42 and cysteine 66

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 6 between cysteines 57 and 66 (61 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

55

PDB code

Structure name

solution structure of the ch domain of human rho guanine nucleotide exchange factor 6

Structure deposition date

2005-02-15

Thiol separation (Å)

7

Half-sphere exposure sum ?

59

Minimum pK_a ?

10

% buried

6

Peptide accession

Residue number A

57

Residue number B

66

Peptide name

Rho guanine nucleotide exchange factor 6

Ligandability

Cysteine 57 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 6 between cysteines 42 and 57 (46 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

solution structure of the ch domain of human rho guanine nucleotide exchange factor 6

Structure deposition date

2005-02-15

Thiol separation (Å)

9

Half-sphere exposure sum ?

64

Minimum pK_a ?

10

% buried

30

Peptide accession

Residue number A

42

Residue number B

57

Peptide name

Rho guanine nucleotide exchange factor 6

Ligandability

Cysteine 42 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 6 between cysteines 42 and 77 (46 and 81 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

37

PDB code

Structure name

solution structure of the ch domain of human rho guanine nucleotide exchange factor 6

Structure deposition date

2005-02-15

Thiol separation (Å)

9

Half-sphere exposure sum ?

71

Minimum pK_a ?

11

% buried

54

Peptide accession

Residue number A

42

Residue number B

77

Peptide name

Rho guanine nucleotide exchange factor 6

Ligandability

Cysteine 42 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 6 between cysteines 42 and 66 (46 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

solution structure of the ch domain of human rho guanine nucleotide exchange factor 6

Structure deposition date

2005-02-15

Thiol separation (Å)

10

Half-sphere exposure sum ?

70

Minimum pK_a ?

10

% buried

36

Peptide accession

Residue number A

42

Residue number B

66

Peptide name

Rho guanine nucleotide exchange factor 6

Ligandability

Cysteine 42 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Rho guanine nucleotide exchange factor 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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